{"id":"W1987395036","doi":"10.1007/bf03190076","title":"Metabolism of clozapine by rat brain: the role of flavin-containing monooxygenase (FMO) and cytochrome P450 enzymes","year":2000,"lang":"en","type":"article","venue":"European Journal of Drug Metabolism and Pharmacokinetics","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Clozapine; Flavin-containing monooxygenase; Chemistry; Pharmacology; Monooxygenase; Cytochrome P450; Biochemistry; Metabolism; Biology; Medicine; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001202418,0.0002588062,0.0006976814,0.0001657766,0.00008753824,0.0000326268,0.0002267737,0.00002331864,0.0002952876],"category_scores_gemma":[0.00009084646,0.000159718,0.0001744661,0.0002123716,0.0002681767,0.0001264746,0.00007595075,0.0003991904,0.000004281711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007371159,"about_ca_system_score_gemma":0.00008896577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001686029,"about_ca_topic_score_gemma":8.877811e-7,"domain_scores_codex":[0.9976302,0.0006054407,0.0007777655,0.0001896938,0.0005070817,0.0002898463],"domain_scores_gemma":[0.9985328,0.0002072669,0.0003870325,0.000237136,0.0002354973,0.0004002551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01240375,0.0005432907,0.0005788552,0.000139062,0.001335027,0.0004179752,0.00402008,0.00003908201,0.4848644,0.000603296,0.009450654,0.4856046],"study_design_scores_gemma":[0.02812056,0.0009539995,0.07359664,0.0002314595,0.002187431,0.001054832,0.0008669031,0.0003113154,0.4729264,0.0003523447,0.4190502,0.0003479735],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8254722,0.1715293,0.00001391472,0.001905079,0.00007101655,0.000217476,0.00005868578,0.000006870371,0.0007254761],"genre_scores_gemma":[0.9658648,0.03183822,0.000973622,0.0003846779,0.0004768941,0.00000169073,0.000008535889,0.00004175198,0.0004098428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4852566,"threshold_uncertainty_score":0.651311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00962137449934509,"score_gpt":0.2610835826570633,"score_spread":0.2514622081577182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}