{"id":"W1987419499","doi":"10.1128/jvi.79.7.4316-4328.2005","title":"Tetraspanin CD81 Provides a Costimulatory Signal Resulting in Increased Human Immunodeficiency Virus Type 1 Gene Expression in Primary CD4<sup>+</sup>T Lymphocytes through NF-κB, NFAT, and AP-1 Transduction Pathways","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Biology; NFAT; Jurkat cells; Cell biology; Signal transduction; CD28; Tetraspanin; T-cell receptor; T cell; Transcription factor; Molecular biology; Immune system; Immunology; Gene; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037298,0.0002888969,0.0002025774,0.0001821721,0.0001302907,0.0002793299,0.0001102215,0.0002459858,0.001022268],"category_scores_gemma":[0.0001006571,0.0001378206,0.0002031591,0.0001589149,0.0001575841,0.0001699889,0.0002111293,0.0004847109,0.0003471544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835331,"about_ca_system_score_gemma":0.0001333418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002140836,"about_ca_topic_score_gemma":0.000357745,"domain_scores_codex":[0.9998437,0.00003206605,0.00001635713,0.0000236533,0.0000277349,0.00005644275],"domain_scores_gemma":[0.9999218,0.00002180457,0.00001390828,0.00001175353,0.000007705215,0.00002291398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007365546,0.00001816701,0.00008518668,0.00001504986,0.000001760177,0.00003788483,0.000005879944,0.00002000925,0.999227,0.00002471803,0.00001467629,0.0004759597],"study_design_scores_gemma":[0.00002440311,0.0003625848,0.005486874,0.000004414648,0.00001577709,0.0002707013,0.00002320802,0.0005710173,0.9918851,0.00004288937,0.001310023,0.000003119407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983442,0.0005085834,0.0004179719,0.0000328084,0.00001713541,0.0000106612,0.0001055622,0.00002544681,0.0005376466],"genre_scores_gemma":[0.996887,0.0003440869,0.0009872145,0.00004589256,0.00001663173,0.00002144784,0.0004276072,0.000009865226,0.001260277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022268,"threshold_uncertainty_score":0.003419876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608216795058899,"score_gpt":0.2390373321114888,"score_spread":0.2229551641608998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}