{"id":"W1987421759","doi":"10.1038/gt.2010.125","title":"Readministration of helper-dependent adenoviral vectors to mouse airway mediated via transient immunosuppression","year":2010,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Foundation Fighting Blindness; Cystic Fibrosis Foundation","keywords":"Immune system; Viral vector; Genetic enhancement; Transgene; Biology; Immunology; Immunogenicity; Gene delivery; Adenoviridae; Cyclophosphamide; Vector (molecular biology); Virology; Gene; Recombinant DNA; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003851534,0.0002180187,0.000199363,0.0001028523,0.00008308702,0.00001992094,0.0003984481,0.000226424,0.0002404267],"category_scores_gemma":[0.00002741327,0.0001934749,0.0001143166,0.0001502434,0.00008421893,0.000006005216,0.00004747375,0.0001940767,0.00003448796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001531135,"about_ca_system_score_gemma":0.0001349092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004302223,"about_ca_topic_score_gemma":0.0002763674,"domain_scores_codex":[0.9984028,0.000130146,0.0003241168,0.0004121054,0.0003866134,0.0003442543],"domain_scores_gemma":[0.9988781,0.00001457362,0.00008614636,0.0007010417,0.0001530131,0.0001670841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004554424,0.0002033356,0.0001560866,0.000005281123,0.00006705285,0.000002073751,0.0003185437,0.00007371664,0.9833108,0.000001613811,0.000196722,0.01111033],"study_design_scores_gemma":[0.001213155,0.005314476,0.0007342653,0.000003862225,0.000004586998,0.000007261319,0.00003292774,0.00002205573,0.9889771,0.000008119088,0.003470693,0.0002114615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976748,0.0005309086,0.000560836,0.0002803204,0.0002457761,0.0005081038,0.00006758721,0.00002441278,0.0001072794],"genre_scores_gemma":[0.9979241,0.0004993155,0.0003505865,0.0002345231,0.0002128246,0.00006133435,0.0002725878,0.00005221412,0.0003924813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01089886,"threshold_uncertainty_score":0.7889675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388661190574237,"score_gpt":0.288526556775381,"score_spread":0.2746399448696386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}