{"id":"W1987429110","doi":"10.4161/pri.27962","title":"Safety, specificity and immunogenicity of a PrP<sup>Sc</sup>-specific prion vaccine based on the YYR disease specific epitope","year":2014,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Saskatoon Medical Imaging; University of Saskatchewan","funders":"Alberta Prion Research Institute","keywords":"Immunogenicity; Epitope; Chronic wasting disease; Virology; Disease; Prion protein; Immune system; Biology; Immunology; Computational biology; Medicine; Scrapie; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006371873,0.000262782,0.0002446179,0.0000600793,0.0002227748,0.00005126359,0.0003314771,0.0001207707,0.0001664836],"category_scores_gemma":[0.0001798491,0.0002016074,0.0001890819,0.0001358882,0.00008983493,0.00000874126,0.0001915962,0.0001582767,0.00001802099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003095648,"about_ca_system_score_gemma":0.00005203801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001189292,"about_ca_topic_score_gemma":0.000002897667,"domain_scores_codex":[0.9982241,0.0002682038,0.0003909332,0.0005440495,0.0002777021,0.0002949591],"domain_scores_gemma":[0.9985471,0.00009476687,0.0001903101,0.0008869004,0.00009853704,0.0001823319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007914518,0.0006978993,0.01801418,0.0001937635,0.0001065889,0.000006697698,0.0001350586,0.00245417,0.539816,0.003762299,0.004609299,0.4222895],"study_design_scores_gemma":[0.003520421,0.000915662,0.1660702,0.0002896294,0.00008263622,0.000006735666,0.00006454007,0.01199132,0.1877961,0.001172138,0.6272298,0.0008608176],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739991,0.0180049,0.005620458,0.001193481,0.0001031418,0.0006980476,0.0000639783,0.00002496938,0.0002918579],"genre_scores_gemma":[0.9849802,0.0138681,0.0003455495,0.0002562764,0.000339571,0.00002497305,0.0001207659,0.00003216813,0.00003237612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6226205,"threshold_uncertainty_score":0.8221311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029096951400462,"score_gpt":0.2149391665138093,"score_spread":0.2046481969998047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}