{"id":"W1987429110","doi":"10.4161/pri.27962","title":"Safety, specificity and immunogenicity of a PrP<sup>Sc</sup>-specific prion vaccine based on the YYR disease specific epitope","year":2014,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Saskatoon Medical Imaging; University of Saskatchewan","funders":"Alberta Prion Research Institute","keywords":"Immunogenicity; Epitope; Chronic wasting disease; Virology; Disease; Prion protein; Immune system; Biology; Immunology; Computational biology; Medicine; Scrapie; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005759241,0.0002566771,0.0002735396,0.0002210218,0.0001053607,0.0002809217,0.000152632,0.0003635126,0.0005341249],"category_scores_gemma":[0.0003942288,0.00007579879,0.0002553638,0.00009275285,0.0001869595,0.0002539214,0.0001346224,0.0003551316,0.0002525756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001705702,"about_ca_system_score_gemma":0.0001901239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001682671,"about_ca_topic_score_gemma":0.0001563485,"domain_scores_codex":[0.999761,0.00005707275,0.00002516818,0.00002451295,0.0001026779,0.00002946546],"domain_scores_gemma":[0.999833,0.00003889469,0.00004148041,0.000009825025,0.00006183486,0.00001497086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004385183,0.0001993073,0.001163681,0.0006968815,0.00004039292,0.0003267441,0.00007974241,0.0006108107,0.9336127,0.000927982,0.0004306211,0.06147265],"study_design_scores_gemma":[0.00006391351,0.01098999,0.0072246,0.0001018782,0.00014922,0.003071878,0.00006958433,0.001084427,0.9467975,0.0006450113,0.0297834,0.00001861309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9186969,0.05133016,0.01646811,0.0008200685,0.0002121972,0.0002348992,0.0003909667,0.0001041829,0.01174246],"genre_scores_gemma":[0.9682597,0.01982413,0.006791646,0.0003017533,0.0001065346,0.00006435744,0.0005498241,0.00001937136,0.004082588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005759241,"threshold_uncertainty_score":0.003045857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029096951400462,"score_gpt":0.2149391665138093,"score_spread":0.2046481969998047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}