{"id":"W1987433975","doi":"10.1074/jbc.m113.469916","title":"Zn2+ Mediates High Affinity Binding of Heparin to the αC Domain of Fibrinogen","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Fibrinogen; Antithrombin; Heparin; Chemistry; Plasmin; Thrombin; Fibrin; Biochemistry; Binding site; Platelet; Immunology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072657,0.0003306151,0.0003267867,0.0000842521,0.0002098251,0.0002829711,0.0005027913,0.0002878491,0.0007167408],"category_scores_gemma":[0.0001524315,0.0001463708,0.0001326232,0.00007056979,0.0001981919,0.0001315019,0.0003229392,0.0001923173,0.0003270236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004851054,"about_ca_system_score_gemma":0.0002465733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003168541,"about_ca_topic_score_gemma":0.003163631,"domain_scores_codex":[0.9998444,0.0000226321,0.000007433453,0.00003403616,0.00003387864,0.00005765551],"domain_scores_gemma":[0.999958,0.000005350441,0.000009146227,0.000002725599,0.000008588218,0.00001611624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001946952,0.00002636429,0.0003806516,0.00006197857,0.000005891415,0.0001188112,0.00001818141,0.00008487753,0.9972922,0.0001861196,0.0001435953,0.001486487],"study_design_scores_gemma":[0.00009704212,0.0002028566,0.01066654,0.000008949385,0.00001557638,0.0006065702,0.00004478988,0.003706728,0.9791766,0.0001700794,0.005294105,0.00001018277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860212,0.002469488,0.008132227,0.0001796346,0.0000485969,0.00004767972,0.0001186287,0.0002015463,0.002781119],"genre_scores_gemma":[0.9955468,0.00060194,0.001550899,0.00003912603,0.0000134766,0.00001869539,0.0001270994,0.000009597485,0.002092283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003168541,"threshold_uncertainty_score":0.006300211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02820372562238197,"score_gpt":0.2427826880897078,"score_spread":0.2145789624673258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}