{"id":"W1987433975","doi":"10.1074/jbc.m113.469916","title":"Zn2+ Mediates High Affinity Binding of Heparin to the αC Domain of Fibrinogen","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Fibrinogen; Antithrombin; Heparin; Chemistry; Plasmin; Thrombin; Fibrin; Biochemistry; Binding site; Platelet; Immunology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002809307,0.0000738099,0.0002992341,0.00001560599,0.0000217183,0.000005295187,0.000138627,0.0001096814,0.0004851882],"category_scores_gemma":[0.000252769,0.00003425721,0.000115809,0.00009212357,0.00006936197,0.00002589298,0.00006045363,0.0001630733,0.000006088395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001757441,"about_ca_system_score_gemma":0.00003319675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002710175,"about_ca_topic_score_gemma":3.169617e-7,"domain_scores_codex":[0.9992054,0.00002606115,0.0004197875,0.0000692739,0.0001702856,0.0001092529],"domain_scores_gemma":[0.9992275,0.00009510545,0.0002978404,0.0001177456,0.000168628,0.00009317479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000152676,0.00007874206,0.03581705,0.00005482731,0.00005619762,0.000002975843,0.00005858159,0.00001130659,0.9616996,0.000009224527,0.0005486333,0.001510169],"study_design_scores_gemma":[0.0004162043,0.000389562,0.109755,0.00009758588,0.00003373965,0.00006146428,0.0002372766,0.000007725949,0.8881845,0.000279609,0.0004898384,0.0000474881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971473,0.0002947159,0.00001387107,0.00194797,0.00003907616,0.00008319721,0.000004348611,0.000003644762,0.0004659333],"genre_scores_gemma":[0.9986548,0.00006550932,0.0008445253,0.00009209495,0.0002464091,0.000002134549,0.00000341297,0.000003438712,0.00008766512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07393798,"threshold_uncertainty_score":0.531247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02820372562238197,"score_gpt":0.2427826880897078,"score_spread":0.2145789624673258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}