{"id":"W1987460161","doi":"10.1021/jm501759m","title":"Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agentschap voor Innovatie door Wetenschap en Technologie; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Seventh Framework Programme; AbbVie; Canadian Institutes of Health Research; Wellcome; GlaxoSmithKline; National Institute of Allergy and Infectious Diseases; Bayer; Eli Lilly and Company; Boehringer Ingelheim; National Center for Advancing Translational Sciences; Wellcome Trust; American Cancer Society; Doris Duke Charitable Foundation; Stanford University; Pfizer","keywords":"Kinase; Chemistry; Cyclin; Biochemistry; Virology; Biology; Cell cycle; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284381,0.0002495026,0.0002083238,0.0002789512,0.0001196139,0.0002121415,0.0002382862,0.0001775422,0.0009106337],"category_scores_gemma":[0.00007984665,0.00009390319,0.0001425267,0.0001894885,0.0001272687,0.0001576769,0.0002067278,0.0003234032,0.0002783248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090526,"about_ca_system_score_gemma":0.0002162467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005064916,"about_ca_topic_score_gemma":0.002282038,"domain_scores_codex":[0.9999378,0.00001338994,0.000003914152,0.00001066085,0.00001623198,0.00001808643],"domain_scores_gemma":[0.9999799,0.000003443367,0.000004360827,0.000001864298,0.000004113016,0.00000623957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003948584,0.0002220076,0.0005304053,0.0004843241,0.00004001669,0.0003914685,0.00007035656,0.001504347,0.9243207,0.002777032,0.001120206,0.06814422],"study_design_scores_gemma":[0.0004176972,0.002817474,0.00477196,0.0000736323,0.00009310978,0.001482218,0.00005796136,0.003743169,0.9156789,0.0004909089,0.07034025,0.00003275897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8735063,0.0934442,0.0103427,0.0004605656,0.0002409604,0.0003039018,0.0005440355,0.0003313112,0.02082598],"genre_scores_gemma":[0.9563912,0.03284263,0.005109623,0.0002249233,0.00004115246,0.00007958183,0.0003008248,0.00001474689,0.004995385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009106337,"threshold_uncertainty_score":0.003046393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02845496752802748,"score_gpt":0.3313140330925284,"score_spread":0.3028590655645009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}