{"id":"W1987508250","doi":"10.1021/mp049917l","title":"Disulfiram Metabolites Permanently Inactivate the Human Multidrug Resistance P-Glycoprotein","year":2004,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Disulfiram; Chemistry; P-glycoprotein; Pharmacology; Aldehyde dehydrogenase; ATP-binding cassette transporter; Multiple drug resistance; Dithiothreitol; Sulfone; Cisplatin; Cysteine; Biochemistry; Enzyme; Chemotherapy; Transporter; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000271814,0.0003102612,0.0003426312,0.0000801522,0.0003218927,0.00004486942,0.0002795231,0.00009913396,0.00007086204],"category_scores_gemma":[0.00002107965,0.0002156561,0.0002411705,0.0003345796,0.0001974796,0.00008072098,0.00004419261,0.0005266025,0.0000535696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001179041,"about_ca_system_score_gemma":0.00009226365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002167573,"about_ca_topic_score_gemma":0.00002217967,"domain_scores_codex":[0.9981228,0.00005953323,0.0003539803,0.0003869577,0.0005790092,0.0004977943],"domain_scores_gemma":[0.9989564,0.00001553972,0.0001107264,0.0005910058,0.0001081636,0.0002181423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001393723,0.0002875257,0.0001825071,0.0001549658,0.0001678334,0.000681801,0.0005011854,0.0000852644,0.9862453,0.01098119,0.00005896134,0.0005141048],"study_design_scores_gemma":[0.002993204,0.00003338259,0.001354306,0.0001308287,0.0003759158,0.00002899149,0.0001416785,0.00002980345,0.9035648,0.00213305,0.08894894,0.0002650772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801406,0.004578027,0.004342246,0.004686283,0.0002283895,0.001101255,0.00002205693,0.0001889327,0.004712238],"genre_scores_gemma":[0.9923514,0.0002105168,0.002536162,0.001917069,0.0001207676,0.00007213361,0.00005402806,0.00007400181,0.002663892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08888998,"threshold_uncertainty_score":0.8794202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967459012867595,"score_gpt":0.3136729503249934,"score_spread":0.2939983601963174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}