{"id":"W1987508250","doi":"10.1021/mp049917l","title":"Disulfiram Metabolites Permanently Inactivate the Human Multidrug Resistance P-Glycoprotein","year":2004,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Disulfiram; Chemistry; P-glycoprotein; Pharmacology; Aldehyde dehydrogenase; ATP-binding cassette transporter; Multiple drug resistance; Dithiothreitol; Sulfone; Cisplatin; Cysteine; Biochemistry; Enzyme; Chemotherapy; Transporter; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312302,0.0002789119,0.0002549814,0.0001060647,0.00008417365,0.0001593252,0.0001610148,0.0002354124,0.001155854],"category_scores_gemma":[0.0002000802,0.0001396731,0.000223935,0.0001133194,0.0001649604,0.0001680524,0.0001454762,0.0003154562,0.0002488659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001672968,"about_ca_system_score_gemma":0.0001933672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006053526,"about_ca_topic_score_gemma":0.001073898,"domain_scores_codex":[0.9999021,0.00003132965,0.000009285312,0.00001247765,0.00002946788,0.00001528604],"domain_scores_gemma":[0.9998966,0.0000282009,0.00003502303,0.0000140573,0.0000120715,0.00001399602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001560335,0.00003888256,0.0003934503,0.00007062565,0.00001930868,0.00005930914,0.00002287603,0.00008846386,0.995522,0.0001354347,0.00006557452,0.003427893],"study_design_scores_gemma":[0.00003533638,0.001300574,0.004022168,0.00000679604,0.00002737937,0.0001753581,0.0000164448,0.0003996976,0.9900096,0.0000376923,0.003965402,0.000003592355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918321,0.003804514,0.001649367,0.0001468921,0.00004520491,0.00006288518,0.0002166934,0.00006716051,0.002175164],"genre_scores_gemma":[0.99286,0.002739522,0.001946674,0.00007187963,0.00003068263,0.00002713111,0.0003509052,0.00001065162,0.001962522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155854,"threshold_uncertainty_score":0.003866732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967459012867595,"score_gpt":0.3136729503249934,"score_spread":0.2939983601963174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}