{"id":"W1987553252","doi":"10.1006/jmbi.2001.5058","title":"A new and efficient DNA enzyme for the sequence-specific cleavage of RNA","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"National Research Council Canada; Canadian Institutes of Health Research; National Science Council","keywords":"Deoxyribozyme; Ribozyme; RNA; DNA; Cleavage (geology); Mammalian CPEB3 ribozyme; Enzyme kinetics; VS ribozyme; Ribonucleotide; Ligase ribozyme; Chemistry; Hairpin ribozyme; Biology; Nucleotide; Biochemistry; Enzyme; Active site; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003489038,0.0001220529,0.0002311043,0.00006911359,0.00004891527,0.000009107374,0.0001964419,0.0001411035,0.000001235397],"category_scores_gemma":[0.0001192484,0.00007626211,0.0001798347,0.0001197381,0.0001678695,0.000001709172,0.00005692089,0.00009320539,1.594934e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009590681,"about_ca_system_score_gemma":0.00006282804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004206497,"about_ca_topic_score_gemma":0.000002711851,"domain_scores_codex":[0.9991696,0.00006302239,0.0003503787,0.0001679285,0.00008092396,0.0001680718],"domain_scores_gemma":[0.9991262,0.00004227864,0.0003412188,0.0002180576,0.000206561,0.00006570295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002037423,0.00002431494,0.00008067991,0.000003616052,0.000102189,0.000008638746,0.00001164217,0.00003471554,0.97949,0.0003105537,0.001116302,0.01861365],"study_design_scores_gemma":[0.0004451849,0.000793542,0.00008426882,0.00001534578,0.00005906436,0.000252637,0.00004511541,0.00005338981,0.9597341,0.0005414151,0.03788231,0.00009364437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6382505,0.005936475,0.3547125,0.0007523155,0.00009914721,0.0001356087,0.000009328866,0.00000442345,0.00009969054],"genre_scores_gemma":[0.9764961,0.002065703,0.02099473,0.0002109076,0.0001582181,0.000001332102,0.000007127403,0.0000112529,0.00005462243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3382456,"threshold_uncertainty_score":0.3109878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174986494713748,"score_gpt":0.3003636196533435,"score_spread":0.2828649701819687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}