{"id":"W1987562799","doi":"10.1021/bi030227h","title":"Changes in the Kinetics and Emission Spectrum on Mutation of the Chromophore-Binding Platform in <i>Vibrio harveyi</i> Luciferase","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Flavin group; Luciferase; Chromophore; Chemistry; Stereochemistry; Binding site; Mutant; Active site; Photochemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139514,0.0003003786,0.0002077004,0.0001129833,0.00009671994,0.0002198559,0.0003494098,0.0003543345,0.001014278],"category_scores_gemma":[0.0003519299,0.0001398706,0.0002933396,0.0001340899,0.000343682,0.0001560931,0.0001480892,0.0006829122,0.0003748655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006098313,"about_ca_system_score_gemma":0.0001510664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002003913,"about_ca_topic_score_gemma":0.000980649,"domain_scores_codex":[0.999833,0.00002605246,0.000009132219,0.00003847823,0.00004714982,0.00004606603],"domain_scores_gemma":[0.9996555,0.0001190988,0.00009779783,0.00003333922,0.00004166992,0.00005257494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001700029,0.00003239035,0.000380122,0.0000191252,0.000005364499,0.00003558052,0.00003554844,0.0001620341,0.9982587,0.00006743271,0.00004551387,0.0007882593],"study_design_scores_gemma":[0.00001134175,0.0001648391,0.005531036,0.00000366123,0.000007296129,0.0000955582,0.00003036959,0.002820258,0.9909739,0.00004398463,0.0003072894,0.00001043531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968678,0.0001994929,0.001966618,0.00006664729,0.00001442691,0.00001105377,0.0001988617,0.0001100792,0.0005651104],"genre_scores_gemma":[0.9979358,0.0001263612,0.0009324613,0.0000373646,0.000003815986,0.00001541013,0.0002432786,0.00004726329,0.0006583109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002003913,"threshold_uncertainty_score":0.004424632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361875574254624,"score_gpt":0.2569583864624246,"score_spread":0.2433396307198784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}