{"id":"W1987571005","doi":"10.1371/journal.pone.0014462","title":"Enhancement of Vaccinia Virus Based Oncolysis with Histone Deacetylase Inhibitors","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Ottawa Hospital; University of Ottawa; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Ontario Institute for Cancer Research","keywords":"Oncolytic virus; Vaccinia; Trichostatin A; Histone deacetylase; Virology; Biology; Vesicular stomatitis virus; Virus; Histone deacetylase inhibitor; Cancer research; Viral replication; Immunology; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487538,0.0001562509,0.0002223688,0.00008097129,0.00005497823,0.000009753032,0.0002210597,0.0001229772,0.0004022028],"category_scores_gemma":[0.00005617523,0.0001400889,0.00006566436,0.0001563385,0.00009880231,0.000003065777,0.00005815452,0.0001829767,0.00002743667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002497206,"about_ca_system_score_gemma":0.0002265302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004452936,"about_ca_topic_score_gemma":0.000930736,"domain_scores_codex":[0.9987271,0.00005624697,0.0002184773,0.0003268988,0.0004107069,0.0002605824],"domain_scores_gemma":[0.998937,0.0000169457,0.000108723,0.0006126129,0.0001979646,0.0001267743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002792436,0.001888224,0.0005254197,0.00004691313,0.0002387709,0.000002921101,0.00002223266,0.000006489972,0.9933479,0.000002144729,0.0001981128,0.0009284549],"study_design_scores_gemma":[0.001218949,0.004892818,0.0001440041,0.00002969662,0.00006760069,5.52277e-7,0.000008303256,0.00007784867,0.9929702,0.000003052493,0.0004150546,0.0001719712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987177,0.0002002971,0.00009006044,0.0002097662,0.0000247871,0.0003104471,0.00002165043,0.00001213076,0.000413146],"genre_scores_gemma":[0.9961486,0.00006128752,0.002731194,0.0001618826,0.0001499834,0.00008336196,0.00006906389,0.00003606628,0.0005585275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003004594,"threshold_uncertainty_score":0.5712658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901505313410881,"score_gpt":0.2736722943518295,"score_spread":0.2546572412177207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}