{"id":"W1987571005","doi":"10.1371/journal.pone.0014462","title":"Enhancement of Vaccinia Virus Based Oncolysis with Histone Deacetylase Inhibitors","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Ottawa Hospital; University of Ottawa; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Ontario Institute for Cancer Research","keywords":"Oncolytic virus; Vaccinia; Trichostatin A; Histone deacetylase; Virology; Biology; Vesicular stomatitis virus; Virus; Histone deacetylase inhibitor; Cancer research; Viral replication; Immunology; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799249,0.0002901476,0.0003317973,0.0001647972,0.00007478644,0.0002347888,0.0001901064,0.0001638006,0.0007973242],"category_scores_gemma":[0.0001308858,0.00009866698,0.0002977807,0.0001100472,0.000148202,0.0001820129,0.0001315885,0.0004194857,0.0001861331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236077,"about_ca_system_score_gemma":0.0001643361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005356062,"about_ca_topic_score_gemma":0.0009351288,"domain_scores_codex":[0.9998906,0.00002239381,0.00001342863,0.00001703228,0.00002805122,0.00002845904],"domain_scores_gemma":[0.9999185,0.00002749342,0.00001981365,0.00001018273,0.000009832135,0.00001435297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000935059,0.00002690736,0.00009065669,0.00002958236,0.000005515189,0.00001308309,0.000008308465,0.0001045694,0.9981601,0.00005985542,0.00001884478,0.001389103],"study_design_scores_gemma":[0.000009349361,0.0005019025,0.0006299385,0.000001744768,0.00001050427,0.00004406436,0.000005165334,0.0004109204,0.9975097,0.00001036637,0.0008649747,0.000001304653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907711,0.00241829,0.004416019,0.00007356249,0.0000470001,0.00006557388,0.0002694091,0.00007921761,0.001859903],"genre_scores_gemma":[0.9934949,0.001427586,0.003187286,0.00002314314,0.00001352795,0.00003081292,0.0002547753,0.00001705501,0.001550988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007973242,"threshold_uncertainty_score":0.002667367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901505313410881,"score_gpt":0.2736722943518295,"score_spread":0.2546572412177207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}