{"id":"W1987575412","doi":"10.1038/sj.cdd.4401094","title":"HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation","year":2002,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Protease; Apoptosis; Cytochrome c; Caspase; Cell biology; DNA fragmentation; Cleavage (geology); Biology; Cytotoxic T cell; Programmed cell death; NLRP1; Molecular biology; Poly ADP ribose polymerase; Mitochondrion; Chemistry; Biochemistry; Enzyme; In vitro; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003240726,0.000154429,0.0001812361,0.0001274591,0.0001673421,0.00003266157,0.00005132093,0.0001035867,0.0003401428],"category_scores_gemma":[0.00009486738,0.0001314012,0.00002585631,0.0001015962,0.00005836346,0.0001263345,0.00004585167,0.00009737655,0.000275057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002569247,"about_ca_system_score_gemma":0.00002153008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005733533,"about_ca_topic_score_gemma":0.00001260429,"domain_scores_codex":[0.999122,0.00008182658,0.0002025445,0.0002948489,0.00006136697,0.0002374114],"domain_scores_gemma":[0.999536,0.00004935839,0.00008655195,0.0001429257,0.00007241074,0.0001127026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001107984,0.00175244,0.02385299,0.001046917,0.0001863412,0.00006127789,0.00554023,0.00000439832,0.9531702,0.0001812829,0.005196887,0.007899004],"study_design_scores_gemma":[0.02122027,0.004547746,0.2035522,0.0003217178,0.0006458915,0.0001093022,0.001303772,0.0003527147,0.7624962,0.0002230161,0.004197194,0.001029913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972018,0.0009670367,0.0002391363,0.0001141915,0.00005169329,0.0009381998,0.0001480614,0.00003335896,0.0003065185],"genre_scores_gemma":[0.9981893,0.000220139,0.0001759755,0.00004005278,0.00002150835,0.00009877976,0.0002888636,0.00001473851,0.0009506466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.190674,"threshold_uncertainty_score":0.5358385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680499561440243,"score_gpt":0.2320303514528991,"score_spread":0.2152253558384966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}