{"id":"W1987575412","doi":"10.1038/sj.cdd.4401094","title":"HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation","year":2002,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Protease; Apoptosis; Cytochrome c; Caspase; Cell biology; DNA fragmentation; Cleavage (geology); Biology; Cytotoxic T cell; Programmed cell death; NLRP1; Molecular biology; Poly ADP ribose polymerase; Mitochondrion; Chemistry; Biochemistry; Enzyme; In vitro; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005097885,0.0008055899,0.0006912005,0.0008357642,0.0004916157,0.0006945381,0.0003139126,0.0007996979,0.002216002],"category_scores_gemma":[0.0005191391,0.0003539778,0.00103489,0.0004356806,0.0002912112,0.0007578189,0.0004864675,0.001444763,0.001263471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001025252,"about_ca_system_score_gemma":0.0003141841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007915806,"about_ca_topic_score_gemma":0.001078253,"domain_scores_codex":[0.9994562,0.00007613227,0.00003353625,0.00006263353,0.0001958901,0.000175641],"domain_scores_gemma":[0.9996015,0.00008416074,0.00008559017,0.0000552027,0.0001271576,0.00004636579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006011074,0.0002112947,0.001164569,0.0002198343,0.00007009395,0.0008633753,0.0001052773,0.0002652027,0.9779683,0.001061511,0.0007326906,0.01673675],"study_design_scores_gemma":[0.00005735183,0.0004714168,0.006745721,0.00002237712,0.00002187418,0.002877094,0.0000702061,0.000870979,0.9837589,0.0006371277,0.004451117,0.00001577008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9381945,0.01680961,0.031783,0.0008380017,0.0004270885,0.0004766921,0.001049895,0.0004408187,0.009980395],"genre_scores_gemma":[0.9678507,0.005256956,0.01480639,0.0002994708,0.00009238448,0.0001804906,0.001327614,0.00003242045,0.0101535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002216002,"threshold_uncertainty_score":0.007438719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680499561440243,"score_gpt":0.2320303514528991,"score_spread":0.2152253558384966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}