{"id":"W1987579102","doi":"10.1056/nejmsb1300760","title":"Randomized Clinical Trials — Removing Unnecessary Obstacles","year":2013,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"","keywords":"Medicine; Randomized controlled trial; MEDLINE; Clinical trial; Intensive care medicine; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.1761751,0.0002092682,0.003579841,0.0003182712,0.00006175801,0.00003074959,0.0003791097,0.0004367545,0.003344291],"category_scores_gemma":[0.5809367,0.0001064564,0.0007049253,0.0002520541,0.0009133304,0.0001666468,0.00007991192,0.003989907,0.00006774889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000533311,"about_ca_system_score_gemma":0.001104969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002581474,"about_ca_topic_score_gemma":0.00002364411,"domain_scores_codex":[0.9864582,0.005429678,0.005285861,0.000270412,0.002179044,0.0003767795],"domain_scores_gemma":[0.4714312,0.5146971,0.004562492,0.001213933,0.004618295,0.003476898],"domain_codex":null,"domain_gemma":"methods","domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1574063,0.000321536,0.01129334,0.0002783694,0.001275412,0.0007921839,0.0008135911,0.000005671564,0.002104825,0.003949501,0.0819561,0.7398031],"study_design_scores_gemma":[0.8789132,0.001895645,0.003364099,0.002424784,0.0007447187,0.0007823471,0.0003249604,0.0002210409,0.000124128,0.09466259,0.01642575,0.0001167603],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5851915,0.01494307,0.007835586,0.36129,0.005334367,0.001980575,0.000001679707,0.00005857746,0.0233646],"genre_scores_gemma":[0.9332575,0.01992325,0.00714947,0.00584795,0.02662738,0.000005937212,0.000004805968,0.0000454802,0.007138196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7396864,"threshold_uncertainty_score":0.9983079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6110395323708673,"score_gpt":0.6208620727895252,"score_spread":0.009822540418657932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}