{"id":"W1987604347","doi":"10.1073/pnas.0508562103","title":"The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Fas ligand; Immunological synapse; Cytotoxic T cell; Cell biology; Signal transducing adaptor protein; Biology; Fas receptor; Programmed cell death; T cell; Signal transduction; Apoptosis; Immunology; Biochemistry; T-cell receptor; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317948,0.0002704683,0.0001655661,0.0002285206,0.0004004412,0.0005576743,0.0002646367,0.0003322297,0.00159017],"category_scores_gemma":[0.0002617667,0.0001169548,0.000173143,0.0002064739,0.0002212115,0.0003788061,0.0004455519,0.0003908286,0.001300755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001369286,"about_ca_system_score_gemma":0.0003874349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310975,"about_ca_topic_score_gemma":0.001576343,"domain_scores_codex":[0.9998117,0.00001957957,0.00001022567,0.00004692153,0.00006271512,0.00004885423],"domain_scores_gemma":[0.999893,0.000007337041,0.00002002694,0.00001392087,0.00002688876,0.00003884534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009706178,0.00001356189,0.000534229,0.00004678322,0.000005346509,0.0002050759,0.00001423514,0.0001139357,0.9953237,0.0005289053,0.0001978916,0.002919353],"study_design_scores_gemma":[0.00002727664,0.00007075325,0.01229138,0.00001376184,0.00001943109,0.001671336,0.00004546216,0.005611102,0.9670843,0.0003301895,0.01282326,0.00001170315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754118,0.006393372,0.008402494,0.0006382604,0.0001775229,0.00003186699,0.0001962535,0.0001884852,0.008559839],"genre_scores_gemma":[0.98834,0.0016891,0.002736218,0.0001238516,0.00003303428,0.00001527741,0.0003464245,0.00002729577,0.006688826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159017,"threshold_uncertainty_score":0.009934902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927931231963714,"score_gpt":0.2676210811304724,"score_spread":0.2383417688108353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}