{"id":"W1987615467","doi":"10.1016/j.cell.2008.08.017","title":"Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair","year":2008,"lang":"en","type":"article","venue":"Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":481,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Lawrence Berkeley National Laboratory; National Cancer Institute; U.S. Department of Energy; Skaggs Institute for Chemical Biology, Scripps Research Institute; Alberta Heritage Foundation for Medical Research; Canadian Institutes of Health Research; Uehara Memorial Foundation; Heritage Medical Research Institute","keywords":"Biology; Rad50; DNA repair; Replication protein A; Homologous recombination; DNA; Nuclease; Cell biology; Homology directed repair; Molecular biology; Genetics; Nucleotide excision repair; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005222159,0.0004795659,0.0005745805,0.0003309525,0.0006030808,0.001878503,0.0005262475,0.001061701,0.002064161],"category_scores_gemma":[0.0005136768,0.0007473835,0.0002392937,0.0002255668,0.0004302197,0.001422894,0.0006932116,0.001118301,0.00163302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000541148,"about_ca_system_score_gemma":0.000226556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002171654,"about_ca_topic_score_gemma":0.0004344994,"domain_scores_codex":[0.9995772,0.00007734969,0.00003463448,0.0001430785,0.00008888794,0.00007872805],"domain_scores_gemma":[0.9995884,0.00007643947,0.0001018637,0.00007473345,0.00007518553,0.00008334273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002106361,0.00002916584,0.0003251502,0.00003966686,0.000004899369,0.0001160865,0.00006046231,0.0002484,0.9944652,0.001628347,0.000219868,0.00265218],"study_design_scores_gemma":[0.00001105284,0.00006059257,0.001598191,0.000004452866,0.000005615342,0.0002176496,0.00007644061,0.001459788,0.9925168,0.0003291235,0.003710113,0.00001034211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466868,0.008501358,0.03740492,0.0008780049,0.0002008347,0.00005046102,0.00023441,0.0005495572,0.005493628],"genre_scores_gemma":[0.9753607,0.001525887,0.01252961,0.0001302922,0.00005039088,0.00003117647,0.0003395173,0.00009372725,0.009938767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002064161,"threshold_uncertainty_score":0.006905317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030389072779447,"score_gpt":0.2175176525811019,"score_spread":0.2072137618533074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}