{"id":"W1987637867","doi":"10.1074/jbc.m411942200","title":"Structural and Mechanistic Analysis of Sialic Acid Synthase NeuB from Neisseria meningitidis in Complex with Mn2+, Phosphoenolpyruvate, and N-Acetylmannosaminitol","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; U.S. Department of Energy; Howard Hughes Medical Institute","keywords":"Sialic acid; Active site; Chemistry; ATP synthase; Biochemistry; Stereochemistry; Protein structure; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001136695,0.0002537983,0.0002936171,0.00009621042,0.0002463895,0.0002329123,0.0003731837,0.0003110351,0.0005391455],"category_scores_gemma":[0.0001731621,0.0001861393,0.0001654828,0.0001277116,0.0002571854,0.0001971232,0.00015898,0.0004297278,0.0001221196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005036439,"about_ca_system_score_gemma":0.0002403251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00477355,"about_ca_topic_score_gemma":0.003753332,"domain_scores_codex":[0.9999486,0.000005893985,0.000001842735,0.00000891387,0.00002280086,0.00001200483],"domain_scores_gemma":[0.9999409,0.000007836101,0.00001344419,0.000004007032,0.000009377305,0.0000244134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003421436,0.00005554405,0.001695868,0.0000878964,0.00002164653,0.0002852992,0.0001520464,0.0009022966,0.9946527,0.000255401,0.0001007591,0.001448215],"study_design_scores_gemma":[0.00008619704,0.0006650759,0.05555245,0.00003053985,0.00005584386,0.0008242328,0.000642039,0.03591343,0.8999581,0.0005291036,0.005682159,0.00006082727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984494,0.0004380571,0.0004169251,0.00008657537,0.000005500355,0.00000558652,0.0001009189,0.00001373918,0.0004832555],"genre_scores_gemma":[0.9976925,0.0004657282,0.0008614826,0.00003604907,0.000005501848,0.00000745696,0.0004184764,0.000008058822,0.0005048349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00477355,"threshold_uncertainty_score":0.009491563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02021965484140126,"score_gpt":0.2396998481609741,"score_spread":0.2194801933195728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}