{"id":"W1987654982","doi":"10.1016/j.cellsig.2008.09.014","title":"The XLP syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation","year":2008,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canada Research Chairs; Ontario Genomics Institute","keywords":"FYN; SH2 domain; SH3 domain; Cell biology; T-cell receptor; Signal transducing adaptor protein; Phosphorylation; Biology; Signal transduction; Tyrosine kinase; Tyrosine phosphorylation; Jurkat cells; Proto-oncogene tyrosine-protein kinase Src; Cell growth; T cell; Biochemistry; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003273009,0.0002364558,0.0002153579,0.0001095485,0.001020966,0.00008293829,0.0001552266,0.0001454061,0.000163336],"category_scores_gemma":[0.00004007471,0.0001658225,0.00005727354,0.0001610593,0.0001216488,0.0002182883,0.00005616897,0.000421713,0.0003501198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005325727,"about_ca_system_score_gemma":0.00006221954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002926542,"about_ca_topic_score_gemma":0.000006824049,"domain_scores_codex":[0.9986215,0.0001892559,0.0003577659,0.0003772748,0.00007836432,0.0003757874],"domain_scores_gemma":[0.9993228,0.00008201056,0.0001662232,0.0002401786,0.0001424432,0.00004629541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004099001,0.00005751976,0.00006517471,0.00002533379,0.000057541,0.00002951549,0.0008510106,0.0003223665,0.9976038,0.00008524289,0.0002099863,0.0002826396],"study_design_scores_gemma":[0.0006519158,0.0006587041,0.0001300116,0.0001681527,0.00002394413,0.0002867491,0.0002696346,0.0001829343,0.9854798,0.00002685442,0.01187371,0.0002476133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810088,0.001254488,0.01517828,0.0002932721,0.0004355028,0.001212728,7.437855e-7,0.00009603429,0.0005201968],"genre_scores_gemma":[0.9812845,0.00002446514,0.0004156673,0.0001311187,0.00004368313,0.0001512844,0.00003918639,0.00003566427,0.01787446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01735426,"threshold_uncertainty_score":0.7852548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023104824862277,"score_gpt":0.1859027546897496,"score_spread":0.1756717064411268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}