{"id":"W1987654982","doi":"10.1016/j.cellsig.2008.09.014","title":"The XLP syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation","year":2008,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canada Research Chairs; Ontario Genomics Institute","keywords":"FYN; SH2 domain; SH3 domain; Cell biology; T-cell receptor; Signal transducing adaptor protein; Phosphorylation; Biology; Signal transduction; Tyrosine kinase; Tyrosine phosphorylation; Jurkat cells; Proto-oncogene tyrosine-protein kinase Src; Cell growth; T cell; Biochemistry; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288323,0.0004355922,0.0001808809,0.0002670244,0.0003015156,0.0004416346,0.0002004153,0.000323372,0.001380323],"category_scores_gemma":[0.0001799861,0.0001814264,0.0002989595,0.0001893031,0.0002878691,0.0002737133,0.0004283891,0.0006284416,0.0007308683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003592813,"about_ca_system_score_gemma":0.0001168801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003890801,"about_ca_topic_score_gemma":0.0005949342,"domain_scores_codex":[0.9998739,0.00002039181,0.000006329414,0.00001965367,0.00003575231,0.00004402124],"domain_scores_gemma":[0.9998896,0.00002547519,0.00003060357,0.00001093171,0.00001022644,0.00003304008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001972431,0.00001111657,0.001385267,0.00002459647,0.00001036308,0.0004183139,0.00001773568,0.0001260189,0.9949145,0.0002422411,0.000200051,0.00245255],"study_design_scores_gemma":[0.00007224537,0.0002297458,0.05356563,0.00001142689,0.00003805311,0.002493925,0.0001124489,0.004214472,0.9326682,0.0007528916,0.005824394,0.00001664338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994186,0.001935752,0.001729355,0.0001095575,0.00002913608,0.000004299647,0.0001349605,0.00006524508,0.001805744],"genre_scores_gemma":[0.9960806,0.0006060203,0.0008753399,0.00006898397,0.00001868589,0.000009019417,0.0003085405,0.00001952154,0.002013447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001380323,"threshold_uncertainty_score":0.004617631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023104824862277,"score_gpt":0.1859027546897496,"score_spread":0.1756717064411268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}