{"id":"W1987704635","doi":"10.1073/pnas.1004250107","title":"Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Metalloenzymes and iron-sulfur proteins","field":"Energy","cited_by":404,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Max-Planck-Gesellschaft; Leibniz-Gemeinschaft; Deutsche Forschungsgemeinschaft","keywords":"Adrenodoxin; Ferredoxin; Biochemistry; Iron–sulfur cluster; Heme; Biology; Biosynthesis; Cholesterol side-chain cleavage enzyme; Cytochrome P450; Mitochondrion; Biogenesis; Heme A; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305538,0.0005318837,0.0002439526,0.0003048387,0.0002684864,0.0003484765,0.0002529428,0.0005921481,0.001607459],"category_scores_gemma":[0.0002118634,0.0001546035,0.0002879441,0.0001719351,0.000311616,0.000298735,0.0003696885,0.0002993054,0.0004767981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569258,"about_ca_system_score_gemma":0.0001453321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006744213,"about_ca_topic_score_gemma":0.0004643217,"domain_scores_codex":[0.9998989,0.000008610295,0.000006309226,0.00005152691,0.00001823947,0.00001641591],"domain_scores_gemma":[0.9998834,0.00001793394,0.0000405555,0.00001486087,0.00001608863,0.00002716072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001027769,0.0001233041,0.0384027,0.0001903441,0.0001109871,0.001742863,0.0003658993,0.0002155894,0.9172385,0.001882405,0.0009427016,0.03775694],"study_design_scores_gemma":[0.0001646992,0.001315392,0.5450616,0.00009921099,0.0001942553,0.02821634,0.0004656193,0.002157908,0.3528027,0.002433808,0.0669935,0.00009489991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831561,0.004731354,0.009175919,0.0004433077,0.00006731686,0.00003188116,0.000710407,0.0001756321,0.001508225],"genre_scores_gemma":[0.986944,0.001031554,0.006071933,0.0002123838,0.00003370194,0.00002649118,0.001345358,0.00001523607,0.004319433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607459,"threshold_uncertainty_score":0.005377471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02172184960511059,"score_gpt":0.2713513565435551,"score_spread":0.2496295069384445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}