{"id":"W1987728909","doi":"10.12688/f1000research.4097.1","title":"Thiolation-enhanced substrate recognition by D-alanyl carrier protein ligase DltA from Bacillus cereus","year":2014,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Saskatchewan Health Research Foundation","keywords":"Alanine; DNA ligase; Adenylylation; Biochemistry; Allosteric regulation; Substrate (aquarium); Stereochemistry; Coenzyme A; Biology; Chemistry; Enzyme; Biosynthesis; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336822,0.0003421657,0.0004111024,0.0001152488,0.0001149539,0.0003810009,0.0002281968,0.0003507349,0.0008093347],"category_scores_gemma":[0.0002469356,0.0001531881,0.0002796756,0.0002591108,0.0001543956,0.0002220293,0.0003414863,0.0004901486,0.0007252293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000458219,"about_ca_system_score_gemma":0.0002030867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001655245,"about_ca_topic_score_gemma":0.00148507,"domain_scores_codex":[0.9998283,0.0000241631,0.00001765929,0.00003972284,0.00005434116,0.00003579875],"domain_scores_gemma":[0.9999171,0.00001219581,0.00002168459,0.000008851987,0.00001615644,0.00002389772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006026175,0.0000108565,0.0001574779,0.00004665807,0.000002603192,0.00002783679,0.00001070916,0.00003856774,0.9985488,0.00003465488,0.00003069989,0.001030884],"study_design_scores_gemma":[0.0000140711,0.00008907764,0.002097629,0.000004964364,0.000007625513,0.0001935604,0.00002595115,0.0009444464,0.9946082,0.00002465363,0.001983679,0.000006119347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935833,0.001404121,0.003001533,0.0002186357,0.00003967419,0.00002077066,0.0003719122,0.0001217548,0.00123835],"genre_scores_gemma":[0.9882123,0.000782876,0.005605075,0.00007647928,0.000009974317,0.00002665572,0.001490345,0.00005324744,0.003743008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655245,"threshold_uncertainty_score":0.003324687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02121613791171979,"score_gpt":0.2785910311730767,"score_spread":0.2573748932613569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}