{"id":"W1987741335","doi":"10.1038/sj.mt.6300403","title":"A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; Oncolytics Biotech (Canada); University of Calgary","funders":"","keywords":"Medicine; Virology; Pathology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008767967,0.001448599,0.001553744,0.0003992394,0.0003291784,0.0006271552,0.0007359701,0.00101781,0.001705213],"category_scores_gemma":[0.0006682557,0.0004217896,0.000887128,0.0003061041,0.0007466531,0.0005706066,0.0002609372,0.002311389,0.0004852282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007525847,"about_ca_system_score_gemma":0.0008836834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092167,"about_ca_topic_score_gemma":0.002118102,"domain_scores_codex":[0.9997092,0.0001280006,0.00001546704,0.00004781037,0.00002648121,0.00007298921],"domain_scores_gemma":[0.9995803,0.0000845492,0.00009837414,0.00005004948,0.00002463659,0.000162034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6503226,0.05548889,0.005779197,0.001270423,0.001560263,0.0008362826,0.0008714156,0.004871459,0.1097585,0.0008029985,0.003764025,0.164674],"study_design_scores_gemma":[0.3261091,0.6540231,0.007297003,0.00003814285,0.0003635862,0.0004843793,0.00009395046,0.001823732,0.007292655,0.0002400375,0.002199447,0.0000347353],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949012,0.001417881,0.0004941049,0.0001902696,0.0001012354,0.001334882,0.0002063607,0.00008593456,0.001268084],"genre_scores_gemma":[0.9945508,0.001043354,0.0008001833,0.0002505162,0.00008947289,0.001291382,0.0005317942,0.0000201058,0.001422366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705213,"threshold_uncertainty_score":0.005704463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584841546116342,"score_gpt":0.3050530859248438,"score_spread":0.2792046704636804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}