{"id":"W1987741335","doi":"10.1038/sj.mt.6300403","title":"A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; Oncolytics Biotech (Canada); University of Calgary","funders":"","keywords":"Medicine; Virology; Pathology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002283929,0.0001841827,0.000304077,0.0001141388,0.00002986479,0.000004624487,0.0002288424,0.0001297234,0.0000282942],"category_scores_gemma":[0.00003930868,0.0001493403,0.0001007848,0.0002240011,0.0002466124,0.000004111545,0.0000246938,0.000104676,0.00000116046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002246331,"about_ca_system_score_gemma":0.0002915958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001172128,"about_ca_topic_score_gemma":0.00003021064,"domain_scores_codex":[0.9983661,0.0002490792,0.0004274358,0.0003344103,0.0003764425,0.0002465754],"domain_scores_gemma":[0.9990892,0.000009702056,0.000212753,0.0004183739,0.0001981959,0.00007179665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3413091,0.00279229,0.0007317847,0.000008234041,0.00006118767,0.00005125477,0.00004949341,0.000008077232,0.6498374,0.00002234939,0.00002074801,0.005108114],"study_design_scores_gemma":[0.07870579,0.07913239,0.001451977,0.00001565488,0.000005483763,0.000006317034,0.000006149858,0.000007098196,0.840122,0.00002190758,0.0003631455,0.000162129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981086,0.0005962843,0.0001876082,0.00004256899,0.00005124365,0.0008850343,0.00002647801,0.000005835876,0.00009634791],"genre_scores_gemma":[0.9991781,0.0002300276,0.0002322953,0.0000677659,0.00002270805,0.00006036645,0.0001626406,0.00002326428,0.000022796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2626033,"threshold_uncertainty_score":0.6089921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584841546116342,"score_gpt":0.3050530859248438,"score_spread":0.2792046704636804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}