{"id":"W1987749248","doi":"10.1124/mol.104.002956","title":"Molecular Basis for the Differential Agonist Affinities of Group III Metabotropic Glutamate Receptors","year":2004,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Affinities; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor; Metabotropic glutamate receptor 4; Agonist; Metabotropic glutamate receptor 3; Metabotropic receptor; Class C GPCR; Metabotropic glutamate receptor 5; Chemistry; Receptor; Metabotropic glutamate receptor 6; Metabotropic glutamate receptor 7; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002544842,0.0003236278,0.0004251082,0.0002341727,0.0005619926,0.00006063699,0.001202235,0.0001115798,0.0003313271],"category_scores_gemma":[0.0002699341,0.0002519062,0.0003365632,0.0006275564,0.001496719,0.0001399291,0.0003503665,0.0004371305,0.00002919022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005572766,"about_ca_system_score_gemma":0.0001624389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000200084,"about_ca_topic_score_gemma":0.00000176574,"domain_scores_codex":[0.996869,0.0005517706,0.0004496019,0.0007672257,0.0005000078,0.0008624398],"domain_scores_gemma":[0.9984699,0.0007063233,0.000204338,0.0003640237,0.0000906584,0.000164716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004171206,0.0003205644,0.000006857611,0.00003437562,0.00004806244,0.000266735,0.00009239899,0.0009580003,0.990027,0.007005427,0.0002385415,0.000584906],"study_design_scores_gemma":[0.002750283,0.0006068542,0.00004370465,0.000005939081,0.0002072046,0.00004768269,0.00002823064,0.0004144514,0.9907885,0.0005766056,0.004310905,0.0002197023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839252,0.0002518523,0.0080413,0.002992669,0.003221567,0.001250621,0.00004707101,0.00008851897,0.0001812095],"genre_scores_gemma":[0.9935069,0.000444433,0.00007839534,0.005244785,0.0001169293,0.0004374525,0.000001749517,0.0000566435,0.0001127049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009581717,"threshold_uncertainty_score":0.9999933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03596358556908827,"score_gpt":0.3300411607132571,"score_spread":0.2940775751441688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}