{"id":"W1987769201","doi":"10.1371/journal.pone.0013847","title":"Cortactin Phosphorylated by ERK1/2 Localizes to Sites of Dynamic Actin Regulation and Is Required for Carcinoma Lamellipodia Persistence","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institutes of Health; West Virginia University; University of Rochester; Division of Graduate Education; University of Toronto; AstraZeneca","keywords":"Cortactin; Phosphorylation; Lamellipodium; Tyrosine phosphorylation; Cell biology; Biology; Actin cytoskeleton; Actin; Pseudopodia; Cytoskeleton; Biochemistry; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007011733,0.00009271491,0.0001266229,0.00002897392,0.000056244,0.00001516015,0.00007506266,0.0001244792,0.00006813328],"category_scores_gemma":[0.0001086412,0.00009901028,0.00004692739,0.00005522752,0.00002752793,0.000005456181,0.00003621832,0.00007096752,0.000003192129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007892741,"about_ca_system_score_gemma":0.00002055888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003834015,"about_ca_topic_score_gemma":0.00009560792,"domain_scores_codex":[0.9993792,0.000009666337,0.0001496826,0.0002479455,0.00009136616,0.0001221613],"domain_scores_gemma":[0.9994434,0.00001744762,0.00008488051,0.0002282553,0.0001603354,0.00006569304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001199393,0.0001702402,0.0004671487,0.00003185745,0.00006564154,1.112241e-7,0.00007073478,3.532485e-7,0.9976026,0.00003027534,0.0006788065,0.0007622484],"study_design_scores_gemma":[0.0002480272,0.0004175483,0.0005178886,0.00001814458,0.00006421094,0.000001535883,0.0000666238,0.003787871,0.9919991,0.00003872281,0.002724449,0.0001158182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982609,0.0002746647,0.0006984424,0.000234768,0.00004500329,0.0002711602,0.0001157174,0.000006589217,0.00009273447],"genre_scores_gemma":[0.9958016,0.00007737228,0.002163586,0.00009215064,0.00002798924,0.00002387473,0.000269541,0.00001515465,0.001528681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005603483,"threshold_uncertainty_score":0.4037522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133732243984543,"score_gpt":0.2308008594291294,"score_spread":0.209463536989284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}