{"id":"W1987779367","doi":"10.3389/fimmu.2015.00153","title":"KCa3.1/IK1 Channel Regulation by cGMP-Dependent Protein Kinase (PKG) via Reactive Oxygen Species and CaMKII in Microglia: An Immune Modulating Feedback System?","year":2015,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Microglia; Cell biology; Reactive oxygen species; Protein kinase A; Intracellular; Phosphorylation; Kinase; Chemistry; Signal transduction; Biology; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863055,0.0003903158,0.0006336783,0.0001469043,0.000333728,0.0004899162,0.0004619618,0.001079835,0.0007492297],"category_scores_gemma":[0.0002308511,0.0001996838,0.0007088947,0.0001461375,0.0007723189,0.00143447,0.0002921787,0.0009726495,0.0003162942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007253095,"about_ca_system_score_gemma":0.0004429348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008267506,"about_ca_topic_score_gemma":0.001137233,"domain_scores_codex":[0.9997792,0.00003140599,0.0000159284,0.00003510652,0.00002303273,0.0001153214],"domain_scores_gemma":[0.999876,0.0000101534,0.00003966387,0.00001310691,0.0000210157,0.0000400609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001397548,0.00009766969,0.001369199,0.000472155,0.00003685972,0.000582371,0.0002237433,0.0001964908,0.9866084,0.001316066,0.0005913132,0.007108174],"study_design_scores_gemma":[0.0005047372,0.001373717,0.07162383,0.0003231397,0.0003145204,0.002415163,0.0009675261,0.006609665,0.8951086,0.006145892,0.01452544,0.00008774364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9199329,0.05662714,0.009589975,0.00772984,0.0009747773,0.0001136142,0.0003999414,0.00029023,0.004341497],"genre_scores_gemma":[0.9859301,0.009468038,0.002202585,0.0008398462,0.000225295,0.00008141105,0.00007627226,0.00002107354,0.001155285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079835,"threshold_uncertainty_score":0.005262554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013542970222551,"score_gpt":0.2182084616578465,"score_spread":0.198073031955621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}