{"id":"W1987787628","doi":"10.1371/journal.pone.0075812","title":"Polyhydroxybutyrate Targets Mammalian Mitochondria and Increases Permeability of Plasmalemmal and Mitochondrial Membranes","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Mitochondrion; Membrane; Biophysics; Depolarization; Inner mitochondrial membrane; Membrane potential; Mitochondrial membrane transport protein; Organelle; Mitochondrial permeability transition pore; Polyphosphate; Chemistry; Uniporter; Biochemistry; Polyhydroxybutyrate; Cell biology; Biology; Phosphate; Cytosol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720442,0.0002595259,0.0002891446,0.0001553934,0.0001710161,0.0003825037,0.0002072346,0.0004677458,0.001213094],"category_scores_gemma":[0.0001419159,0.0001690319,0.0002382035,0.0001616241,0.0002275522,0.0003595645,0.0002446446,0.0004719102,0.0003208105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003510177,"about_ca_system_score_gemma":0.0001875803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005573167,"about_ca_topic_score_gemma":0.0007066066,"domain_scores_codex":[0.9998322,0.00003363414,0.00001220693,0.0000407168,0.00004199279,0.00003934465],"domain_scores_gemma":[0.9998686,0.00002589841,0.00004093142,0.00001431155,0.00001795324,0.00003226508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005229576,0.000006528936,0.00004421554,0.00001936016,0.000001531035,0.00001583992,0.00000523097,0.000008615171,0.9994581,0.00002624826,0.0000056097,0.0003563706],"study_design_scores_gemma":[0.00001091658,0.0002306434,0.002729539,0.000006328372,0.00000568133,0.0001842343,0.00001918191,0.0001475279,0.9953228,0.00002364128,0.00131728,0.000002360047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819779,0.00947306,0.005354334,0.0004016474,0.00007420249,0.00005018054,0.0002968227,0.0001288062,0.002243118],"genre_scores_gemma":[0.9884533,0.004220494,0.004159264,0.0001540012,0.00002776634,0.00003979106,0.0002878905,0.00002704694,0.002630418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213094,"threshold_uncertainty_score":0.004058242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0163950168479461,"score_gpt":0.2063640419907934,"score_spread":0.1899690251428474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}