{"id":"W1987841399","doi":"10.1089/10430340260201671","title":"The Canine Factor VIII 3′-Untranslated Region and a Concatemeric Hepatocyte Nuclear Factor 1 Regulatory Element Enhance Factor VIII Transgene Expression <i>In Vivo</i>","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Heart and Stroke Foundation of Canada","keywords":"Transgene; Biology; Molecular biology; Untranslated region; In vivo; Intron; Gene expression; Expression cassette; Reporter gene; Gene; Messenger RNA; Recombinant DNA; Genetics; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000195545,0.0004787073,0.0003689781,0.00009860381,0.0005233015,0.00008813832,0.0005220524,0.0002574298,0.0008249492],"category_scores_gemma":[0.000006443387,0.0003775659,0.0001560658,0.0001873631,0.0002772955,0.00001859946,0.00005862958,0.0002768718,0.00001357686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007640292,"about_ca_system_score_gemma":0.00005188872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005041982,"about_ca_topic_score_gemma":0.0003954464,"domain_scores_codex":[0.997094,0.000384167,0.0005313191,0.0008057455,0.0004257132,0.0007590317],"domain_scores_gemma":[0.9985964,0.0000288752,0.0001739004,0.0008844257,0.00009525587,0.0002211652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001605278,0.0001370712,0.0003905853,0.00001419758,0.0001031919,0.00001234955,0.001070937,0.00001352166,0.9824845,0.000003548784,0.0007125027,0.01345229],"study_design_scores_gemma":[0.002612319,0.002358159,0.002200418,0.00002676414,0.000005676288,0.00001031559,0.00004951199,0.0001229872,0.9581367,0.00001397853,0.03400332,0.0004598431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836881,0.01468805,0.00008055966,0.0002701176,0.00009398987,0.0009609236,0.0000804001,0.00005230305,0.00008563139],"genre_scores_gemma":[0.9780005,0.02023863,0.00004362161,0.0004066485,0.0002004441,0.00009359125,0.00003274726,0.0001250653,0.0008588014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03329081,"threshold_uncertainty_score":0.9998676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03247408166866154,"score_gpt":0.287153374812944,"score_spread":0.2546792931442824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}