{"id":"W1987841399","doi":"10.1089/10430340260201671","title":"The Canine Factor VIII 3′-Untranslated Region and a Concatemeric Hepatocyte Nuclear Factor 1 Regulatory Element Enhance Factor VIII Transgene Expression <i>In Vivo</i>","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Heart and Stroke Foundation of Canada","keywords":"Transgene; Biology; Molecular biology; Untranslated region; In vivo; Intron; Gene expression; Expression cassette; Reporter gene; Gene; Messenger RNA; Recombinant DNA; Genetics; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002625713,0.0003283992,0.0002457068,0.0002246688,0.0001002707,0.0002482216,0.000242309,0.0002948441,0.0007462298],"category_scores_gemma":[0.0001853885,0.0002036878,0.0003232583,0.0001204937,0.0002905988,0.0001869591,0.0001755987,0.0005246499,0.0004295875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003786552,"about_ca_system_score_gemma":0.0003134957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006803056,"about_ca_topic_score_gemma":0.0009447859,"domain_scores_codex":[0.9997593,0.0000431987,0.0000194347,0.0000600809,0.00007615129,0.00004185803],"domain_scores_gemma":[0.9997894,0.00004046176,0.0000890639,0.00001847242,0.00002241481,0.00004023335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002840158,0.00001271152,0.00006322667,0.00001158972,0.000001551772,0.00001088498,0.000005067146,0.00002604864,0.9990782,0.00007827664,0.00001110112,0.0006729754],"study_design_scores_gemma":[0.000008980374,0.0002370249,0.001564813,0.000002931493,0.00001124944,0.0002006072,0.000005740362,0.0004775852,0.994821,0.00003180511,0.002634889,0.000003431567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597381,0.001359671,0.03583923,0.0001417478,0.00004705907,0.00009743227,0.0002337878,0.0003122707,0.002230782],"genre_scores_gemma":[0.9584889,0.0005424412,0.03695967,0.00009336309,0.00002333098,0.00006687292,0.0007132543,0.0001096756,0.003002456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007462298,"threshold_uncertainty_score":0.002747357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03247408166866154,"score_gpt":0.287153374812944,"score_spread":0.2546792931442824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}