{"id":"W1987873124","doi":"10.1021/jm400121t","title":"Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Protease; ADME; Hepatitis C virus; Chemistry; Potency; Protease inhibitor (pharmacology); Virology; NS2-3 protease; Enzyme; Hepacivirus; Virus; In vitro; Biochemistry; Biology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004217218,0.0003820143,0.0005210693,0.0002630266,0.0001497236,0.0004796787,0.0002520718,0.0002373541,0.001022939],"category_scores_gemma":[0.0002603105,0.0001657872,0.0002360964,0.0001759132,0.0002372823,0.0002889065,0.0003311851,0.0005180755,0.0002693302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004581141,"about_ca_system_score_gemma":0.0003419399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004488679,"about_ca_topic_score_gemma":0.001690126,"domain_scores_codex":[0.9998662,0.00003214642,0.000008649567,0.00002278355,0.00004124286,0.00002885508],"domain_scores_gemma":[0.9999202,0.00001194016,0.00002446132,0.000009033727,0.00001598313,0.00001832225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004809823,0.0002157599,0.0009270557,0.0001218815,0.00004100825,0.0003479716,0.00006607703,0.003730326,0.9580362,0.00237873,0.000721865,0.03293203],"study_design_scores_gemma":[0.0003333865,0.003585443,0.003851813,0.00002182537,0.00007835413,0.00100125,0.00003996194,0.01039818,0.9606507,0.0007064244,0.01929514,0.00003751121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695398,0.005734912,0.01662221,0.000603282,0.00005084403,0.0002261937,0.0006236815,0.0002701418,0.006328982],"genre_scores_gemma":[0.9832715,0.002605146,0.01141647,0.0001671265,0.00002129981,0.00003729686,0.000328298,0.00003079917,0.002122027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022939,"threshold_uncertainty_score":0.003422081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007784151182275656,"score_gpt":0.2465635765424652,"score_spread":0.2387794253601896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}