{"id":"W1987889857","doi":"10.1016/j.jmb.2010.11.016","title":"Concerted Dynamics Link Allosteric Sites in the PBX Homeodomain","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Allosteric regulation; Cooperativity; Cooperative binding; Homeobox; Biophysics; Hox gene; DNA; Binding site; Biology; Transcription factor; Ternary complex; DNA binding site; Chemistry; Cell biology; Genetics; Gene; Biochemistry; Gene expression; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003149258,0.0001422212,0.0002878285,0.0001628707,0.0004731926,0.0007106328,0.0005345751,0.000445009,0.003488162],"category_scores_gemma":[0.0006303843,0.0003910424,0.0001753191,0.0001064117,0.0007411753,0.0009196269,0.0006550577,0.0007178601,0.000520098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003034596,"about_ca_system_score_gemma":0.0002234002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003474641,"about_ca_topic_score_gemma":0.000655916,"domain_scores_codex":[0.9998901,0.00001417169,0.000004750646,0.00003066789,0.00003010167,0.00003016667],"domain_scores_gemma":[0.9997317,0.0001168704,0.00003761341,0.00003874951,0.00002075657,0.0000541971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009106534,0.0003420597,0.007290401,0.000115424,0.00004030306,0.0004382684,0.000459245,0.00870836,0.9348055,0.02752014,0.0008771162,0.01849254],"study_design_scores_gemma":[0.0004048508,0.0007826846,0.04005817,0.00002815565,0.00005957749,0.0009478047,0.0007803603,0.2064039,0.6998743,0.04607057,0.004441812,0.0001478308],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907448,0.000165121,0.00732273,0.000232828,0.00003595048,0.000008516079,0.00002600563,0.0001103101,0.001353684],"genre_scores_gemma":[0.9985274,0.00006638836,0.0008948661,0.00002551369,0.000009444453,0.000006352381,0.0000233859,0.00001005139,0.0004365576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003488162,"threshold_uncertainty_score":0.01166904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005145501235834957,"score_gpt":0.2492579536020427,"score_spread":0.2441124523662077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}