{"id":"W1987890298","doi":"10.1073/pnas.1017669108","title":"Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Yale University; National Institutes of Health; University of Alberta; Howard Hughes Medical Institute","keywords":"PKD1; Trimer; Coiled coil; Biophysics; Autosomal dominant polycystic kidney disease; Computational biology; Biology; Cell biology; Genetics; Chemistry; Kidney","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547786,0.0006567974,0.0007569214,0.0004320022,0.0008854251,0.0006415072,0.001404178,0.001554055,0.007140112],"category_scores_gemma":[0.0003171406,0.0003995767,0.0007199576,0.0005881657,0.0005179748,0.0004604437,0.0003921105,0.0005927718,0.0006998382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001128139,"about_ca_system_score_gemma":0.001559418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01242543,"about_ca_topic_score_gemma":0.008516568,"domain_scores_codex":[0.9999136,0.00001743397,0.000003767114,0.00001852031,0.00002332262,0.00002332871],"domain_scores_gemma":[0.9998549,0.00005505233,0.00001724635,0.00001235967,0.00003341437,0.00002699231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001330525,0.0000680746,0.0006541787,0.00008716719,0.00002235976,0.0003778683,0.00005002313,0.9867171,0.006101601,0.003600362,0.0006163953,0.001571821],"study_design_scores_gemma":[0.00005205451,0.00003868773,0.0003067088,0.000006964318,0.000009340678,0.00003109734,0.0000325883,0.9970911,0.0007384791,0.001014506,0.0006690535,0.000009468175],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8753657,0.0007156674,0.08184554,0.0009530823,0.0001313707,0.0001964099,0.005267485,0.001616605,0.0339082],"genre_scores_gemma":[0.9690766,0.0003485434,0.02409857,0.0001030159,0.00002090467,0.0003030555,0.003276857,0.0001554875,0.002616965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01242543,"threshold_uncertainty_score":0.02470618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05388943354499447,"score_gpt":0.2834811510268219,"score_spread":0.2295917174818274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}