{"id":"W1987912093","doi":"10.1016/j.jhep.2009.11.011","title":"Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease","year":2009,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Hôpital Saint-Luc","funders":"Canadian Liver Foundation","keywords":"Innate immune system; NS3; Biology; Hepatitis C virus; Protease; Pattern recognition receptor; Virology; RNA silencing; Immune system; NS2-3 protease; Interferon; RIG-I; Virus; RNA; Gene; RNA interference; Immunology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004802098,0.0002021896,0.0007178987,0.0003308981,0.00009275187,0.00003144393,0.0001253568,0.0001653992,0.0001024867],"category_scores_gemma":[0.0001920362,0.0001482057,0.000124245,0.0001421486,0.0001469327,0.0001849224,0.00004818973,0.0006794358,0.000006322858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001750546,"about_ca_system_score_gemma":0.0001734165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000441116,"about_ca_topic_score_gemma":0.00002637271,"domain_scores_codex":[0.9980528,0.0003076127,0.0007099172,0.0002174709,0.000314716,0.0003975334],"domain_scores_gemma":[0.9991198,0.0001108446,0.0002850386,0.0001534167,0.0001291492,0.0002017357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005254039,0.0004149937,0.6802195,0.00006619181,0.00003314323,0.0005787027,0.0002514615,1.387132e-7,0.2797619,0.00003156895,0.0003151715,0.03780184],"study_design_scores_gemma":[0.008963169,0.005895106,0.9151017,0.0006033723,0.0001036808,0.001214187,0.0001272657,0.001439073,0.06238996,0.002098927,0.001587224,0.000476304],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972109,0.0006123876,0.0003754784,0.000800196,0.00006499966,0.0003629845,0.00001568338,0.00001586015,0.0005415434],"genre_scores_gemma":[0.999235,0.000140234,0.0001746868,0.0001992307,0.0001737346,0.000006531588,0.0000257228,0.00001843955,0.00002644316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2348822,"threshold_uncertainty_score":0.6043652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0267920125254361,"score_gpt":0.3034861957344779,"score_spread":0.2766941832090418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}