{"id":"W1987919585","doi":"10.1139/y99-134","title":"Considerations on pharmacodynamics and pharmacokinetics: Can everything be explained by the extent of drug binding to its receptor?","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacodynamics; Drug; Pharmacokinetics; Pharmacology; Molecular Pharmacology; Biology; Receptor; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006606616,0.001875389,0.005091691,0.001579819,0.001083315,0.003493694,0.004420672,0.007897037,0.003351134],"category_scores_gemma":[0.01866828,0.0007992758,0.001824265,0.001057111,0.01764148,0.01278506,0.002713807,0.01039806,0.001788355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002840423,"about_ca_system_score_gemma":0.002807764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00666392,"about_ca_topic_score_gemma":0.00370946,"domain_scores_codex":[0.996408,0.001574612,0.0002629588,0.0004490843,0.00108701,0.0002183175],"domain_scores_gemma":[0.9879936,0.009038195,0.0007262978,0.0008727231,0.0008561545,0.0005130425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009107598,0.0005209293,0.004935944,0.005224729,0.0006739224,0.001841916,0.0010863,0.01598907,0.007033992,0.6353056,0.03863498,0.2878419],"study_design_scores_gemma":[0.00004255908,0.0004340904,0.002422359,0.0005156751,0.0001034035,0.0009827659,0.0003857564,0.003406433,0.0007463339,0.9261816,0.06466196,0.0001169508],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.009525041,0.5336654,0.1069398,0.3205155,0.006142857,0.00006503348,0.0002923061,0.0003372125,0.02251695],"genre_scores_gemma":[0.2767032,0.5101099,0.0405287,0.1227923,0.03797101,0.0004300624,0.0002739891,0.0003455266,0.01084532],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007897037,"threshold_uncertainty_score":0.03493953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134862769990082,"score_gpt":0.2561481364690696,"score_spread":0.2447995087691688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}