{"id":"W1987924754","doi":"10.1016/j.neulet.2006.08.001","title":"Regulatory sequences of the PRNP gene influence susceptibility to sporadic Creutzfeldt–Jakob disease","year":2006,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"PRNP; Biology; Fatal familial insomnia; Genetics; Kuru; Gene; Disease; Creutzfeldt-Jakob Syndrome; Coding region; Genotype; Virology; Scrapie; Prion protein; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003151748,0.0003965049,0.0002874956,0.0009544034,0.0002279155,0.00034268,0.0002788191,0.000461436,0.001789786],"category_scores_gemma":[0.001179541,0.0002373952,0.0002593906,0.0002920058,0.0005947715,0.0001461209,0.0002108332,0.0004760206,0.0002801872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049479,"about_ca_system_score_gemma":0.0001785651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009322619,"about_ca_topic_score_gemma":0.0008540656,"domain_scores_codex":[0.9996535,0.0001325413,0.0000352602,0.00007022842,0.0000486958,0.00005977822],"domain_scores_gemma":[0.9988398,0.0007160736,0.0001662723,0.00006511274,0.00005649825,0.0001564053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004138962,0.0003450315,0.03118389,0.00005913019,0.00009270247,0.002760832,0.0002659632,0.00055812,0.9540087,0.0008718099,0.00019277,0.005522147],"study_design_scores_gemma":[0.0007336934,0.001648068,0.7518658,0.00006642193,0.0006600111,0.009165287,0.0005620668,0.009416646,0.2205842,0.00283959,0.00236242,0.00009575592],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991462,0.0000968786,0.0003284144,0.00003594803,0.000008045005,0.000005609832,0.00005231844,0.00001328718,0.0003130941],"genre_scores_gemma":[0.9994135,0.00003790839,0.0002326675,0.0000316567,0.000008619792,0.000004892201,0.00004618321,0.00001406766,0.0002105601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001789786,"threshold_uncertainty_score":0.005987406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006582303101134727,"score_gpt":0.2252478222087955,"score_spread":0.2186655191076607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}