{"id":"W1987942363","doi":"10.3389/fonc.2014.00174","title":"A Systemic Review of Resistance Mechanisms and Ongoing Clinical Trials in ALK-Rearranged Non-Small Cell Lung Cancer","year":2014,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Crizotinib; Medicine; Lung cancer; Targeted therapy; Clinical trial; Anaplastic lymphoma kinase; Cancer research; Oncology; Oncogene; Acquired resistance; Cancer; Internal medicine; Bioinformatics; Biology; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00654196,0.0003549703,0.008414513,0.0003777792,0.00002470488,0.000005281539,0.0001652819,0.0006525822,0.00002572612],"category_scores_gemma":[0.001139985,0.0002676631,0.0005502309,0.0003581474,0.00008675504,0.00002493676,0.00004740688,0.0005925235,0.000002121428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001275799,"about_ca_system_score_gemma":0.002357406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001112858,"about_ca_topic_score_gemma":0.0003106339,"domain_scores_codex":[0.9933816,0.002481123,0.003075451,0.000588848,0.0001581229,0.0003148213],"domain_scores_gemma":[0.9963021,0.001258638,0.001805043,0.0004108455,0.00008848596,0.0001349177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009190485,0.0001767218,0.0008651992,0.3503373,0.000440087,0.00009539648,0.0001690971,3.763004e-7,8.009441e-7,0.00002626525,0.02370032,0.6240966],"study_design_scores_gemma":[0.003031478,0.00021497,0.00003212364,0.2902734,0.00567686,0.00001876316,0.00005841134,0.00001407738,3.920653e-7,0.00002565092,0.7004796,0.000174326],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001206163,0.988151,0.001273245,0.000218268,0.001846652,0.00474529,0.00006339303,0.00001200206,0.003678066],"genre_scores_gemma":[0.00002491633,0.9871387,0.0097932,0.0003834058,0.000199429,0.001304398,0.00007738171,0.00005129406,0.00102726],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6767793,"threshold_uncertainty_score":0.9999775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07222494324445801,"score_gpt":0.4877457584565015,"score_spread":0.4155208152120435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}