{"id":"W1987951388","doi":"10.1089/dna.2005.24.351","title":"HER2-Mediated Internalization of a Targeted Prodrug Cytotoxic Conjugate Is Dependent on the Valency of the Targeting Ligand","year":2005,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; National Cancer Institute; National Institute for Health and Care Research; Susan G. Komen; Susan G. Komen for the Cure","keywords":"Internalization; Prodrug; Biology; Cytotoxicity; Cytotoxic T cell; Downregulation and upregulation; Ligand (biochemistry); Cancer research; Conjugate; Receptor; Biochemistry; Cell biology; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122024,0.0002966786,0.0002111676,0.0001331986,0.00009832904,0.0002132057,0.0001470942,0.0001994507,0.0007622173],"category_scores_gemma":[0.0001049022,0.0001345869,0.0001179889,0.0001184342,0.0001531864,0.000158246,0.000138365,0.0002993077,0.0002036529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003854666,"about_ca_system_score_gemma":0.0001901725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003519063,"about_ca_topic_score_gemma":0.0004159481,"domain_scores_codex":[0.9999126,0.00001609816,0.0000071823,0.00001888757,0.00002520396,0.00002011235],"domain_scores_gemma":[0.9999541,0.00001115176,0.00001232305,0.000006442862,0.000007804373,0.000008273271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006811247,0.00002925368,0.00008803386,0.00002994185,0.000004070994,0.0000428104,0.00001332421,0.0002401021,0.9973786,0.0002114989,0.00002460805,0.001869781],"study_design_scores_gemma":[0.0000124484,0.0003106507,0.0005278574,0.000002892516,0.000006273287,0.0001293231,0.000004053666,0.0005536476,0.9977214,0.00002051157,0.0007088866,0.000002074058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929221,0.000599815,0.004321851,0.00003658033,0.000008949814,0.00005227842,0.00005493097,0.00004897815,0.001954497],"genre_scores_gemma":[0.9940228,0.0004636599,0.002649879,0.00003418563,0.000003989202,0.00004137838,0.0001407592,0.00001525701,0.002628146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007622173,"threshold_uncertainty_score":0.002796769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696157687622419,"score_gpt":0.2839249945242098,"score_spread":0.2669634176479856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}