{"id":"W1987978125","doi":"10.14785/lpsn-2014-0016","title":"IPEX syndrome caused by a novel mutation in <i>FOXP3</i> gene can be cured by bone marrow transplantation from an unrelated donor after myeloablative conditioning","year":2014,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; University of Toronto","keywords":"Immune dysregulation; Medicine; Primary immunodeficiency; Hematopoietic stem cell transplantation; Immunology; Enteropathy; FOXP3; Immunodeficiency; Transplantation; Autoimmunity; Immune system; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004249225,0.0002899706,0.0003771533,0.000187566,0.0003875689,0.00007517559,0.0001960343,0.000338251,0.0004261694],"category_scores_gemma":[0.00003092468,0.0002895418,0.00009301143,0.0002354179,0.0001691526,0.0004478293,0.00001164831,0.0004675187,0.00003398204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581528,"about_ca_system_score_gemma":0.0001088326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199014,"about_ca_topic_score_gemma":0.00006574341,"domain_scores_codex":[0.998026,0.000400497,0.0006359004,0.0003513302,0.00009471281,0.0004915457],"domain_scores_gemma":[0.9992519,0.0001372615,0.000335973,0.0001684348,0.00007706993,0.00002937171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004673172,0.0003071942,0.0008050423,0.000007365731,0.0001493256,0.00005796799,0.006466204,0.0002668075,0.9895236,0.00002660615,0.0003532607,0.001569298],"study_design_scores_gemma":[0.06362777,0.002425237,0.1398145,0.0009021009,0.0008231837,0.007197489,0.00537221,0.00273938,0.7645086,0.002480653,0.00715962,0.00294921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720121,0.006777129,0.01940976,0.0004145734,0.0004801796,0.0002109925,0.0005879494,0.0000490161,0.00005827369],"genre_scores_gemma":[0.9949492,0.0001674444,0.00008787667,0.0007630402,0.000006782447,0.00003877198,0.003792197,0.00003443543,0.0001603068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.225015,"threshold_uncertainty_score":0.9999557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00518806229189389,"score_gpt":0.2043275015287485,"score_spread":0.1991394392368546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}