{"id":"W1987978125","doi":"10.14785/lpsn-2014-0016","title":"IPEX syndrome caused by a novel mutation in <i>FOXP3</i> gene can be cured by bone marrow transplantation from an unrelated donor after myeloablative conditioning","year":2014,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; University of Toronto","keywords":"Immune dysregulation; Medicine; Primary immunodeficiency; Hematopoietic stem cell transplantation; Immunology; Enteropathy; FOXP3; Immunodeficiency; Transplantation; Autoimmunity; Immune system; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007837135,0.0004002223,0.0002129231,0.0002008237,0.0002608282,0.0001398553,0.000165381,0.0004868172,0.000744556],"category_scores_gemma":[0.0003632938,0.00007865256,0.0001786545,0.0001009908,0.0003511089,0.0001664363,0.0002243648,0.0004044921,0.0001179725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009161728,"about_ca_system_score_gemma":0.000109937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002389403,"about_ca_topic_score_gemma":0.0002689294,"domain_scores_codex":[0.9999465,0.00000683276,0.000006808173,0.00001459661,0.000009039203,0.00001618438],"domain_scores_gemma":[0.9998819,0.000037269,0.0000387472,0.000009048831,0.000005196049,0.00002788007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0004203241,0.0001168825,0.02435465,0.0001191069,0.00004636607,0.7014167,0.0002276008,0.000225771,0.2502019,0.0007551805,0.0006053833,0.02151014],"study_design_scores_gemma":[0.00006599436,0.0003510985,0.0333948,0.00001897714,0.00004955276,0.9241181,0.00005542664,0.0005848152,0.03821727,0.000222373,0.002911647,0.000009911629],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956985,0.0006958775,0.001943073,0.0002062326,0.00002895675,0.0000170517,0.00003702827,0.0001137957,0.001259438],"genre_scores_gemma":[0.9985507,0.0002681637,0.0006227929,0.00007941681,0.00002801932,0.000006377544,0.00004774322,0.000009112683,0.000387711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000744556,"threshold_uncertainty_score":0.002490759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00518806229189389,"score_gpt":0.2043275015287485,"score_spread":0.1991394392368546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}