{"id":"W1988012381","doi":"10.1016/s0959-440x(00)00135-4","title":"New developments in isotope labeling strategies for protein solution NMR spectroscopy","year":2000,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Isotope; Nuclear magnetic resonance spectroscopy; Stable isotope labeling by amino acids in cell culture; Isotopic labeling; Chemistry; Computational biology; Biochemistry; Proteomics; Biology; Stereochemistry; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001533087,0.0004600273,0.0008755278,0.000255434,0.000061263,0.00003003342,0.0003118876,0.0007385018,0.00009163169],"category_scores_gemma":[0.0000624733,0.0003929345,0.0002066038,0.0002167169,0.00006379307,0.000008450898,0.00009702193,0.0003855342,0.00002011163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008860297,"about_ca_system_score_gemma":0.0007991156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003178882,"about_ca_topic_score_gemma":0.00005434419,"domain_scores_codex":[0.9975501,0.0002655951,0.0008033962,0.0008046847,0.00006102947,0.0005151694],"domain_scores_gemma":[0.9993368,0.00002154663,0.0002622357,0.0002647214,0.00003590249,0.00007872604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001792493,0.00001933793,0.00008414251,0.002820637,0.00003637721,4.18005e-7,0.00003795,0.000007315742,0.004033489,0.001968609,0.001468146,0.9893444],"study_design_scores_gemma":[0.0007826629,0.0002404094,0.00001294591,0.00162551,0.00001466103,0.00001912936,0.000009144715,0.000005792058,0.0001320112,0.001060094,0.9956703,0.0004273351],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003221073,0.9888878,0.002289721,0.00001802021,0.006287729,0.001933904,0.0001205013,0.00001720055,0.000122967],"genre_scores_gemma":[0.00005152292,0.9863485,0.006501307,0.00001289337,0.001560518,0.0003941112,0.004970288,0.00003618103,0.0001246969],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9942021,"threshold_uncertainty_score":0.9998522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07116822920569643,"score_gpt":0.3900828223425839,"score_spread":0.3189145931368875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}