{"id":"W1988012657","doi":"10.1210/me.2002-0120","title":"Bile Acids Induce the Expression of the Human Peroxisome Proliferator-Activated Receptor α Gene via Activation of the Farnesoid X Receptor","year":2003,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":484,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; York University","keywords":"Farnesoid X receptor; Chenodeoxycholic acid; Nuclear receptor; Biology; Peroxisome proliferator-activated receptor; Bile acid; Constitutive androstane receptor; Retinoid X receptor alpha; Retinoid X receptor; CYP8B1; G protein-coupled bile acid receptor; Liver X receptor; Peroxisome proliferator-activated receptor alpha; Small heterodimer partner; Cholic acid; Receptor; Nuclear receptor coactivator 1; Response element; Endocrinology; Biochemistry; Promoter; Gene expression; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145838,0.0004271128,0.0003095109,0.0004514077,0.0001603248,0.0002982933,0.00007055586,0.000169597,0.00257949],"category_scores_gemma":[0.0001922365,0.0002655615,0.0004257608,0.0002867775,0.0002198984,0.0001104392,0.0003051711,0.000426855,0.001204874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002880539,"about_ca_system_score_gemma":0.0002648659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009867375,"about_ca_topic_score_gemma":0.001409129,"domain_scores_codex":[0.9997748,0.00005080536,0.00002360896,0.00003934367,0.00005920232,0.00005221622],"domain_scores_gemma":[0.9998455,0.000031375,0.00003404279,0.00002731291,0.00003165607,0.00002998189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003356472,0.00004351396,0.0003705678,0.00005560263,0.0000109208,0.0001073712,0.0000377889,0.0000390643,0.9965169,0.000074683,0.00008692536,0.002321077],"study_design_scores_gemma":[0.00006417008,0.0007260433,0.01489851,0.0000209902,0.00002670508,0.0003789837,0.0001002835,0.0005670931,0.9746475,0.0001398302,0.008419733,0.00001016584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97826,0.008434422,0.004731243,0.0003824622,0.0001808037,0.0001246309,0.001243092,0.0002514516,0.006391966],"genre_scores_gemma":[0.9729506,0.005020323,0.003846061,0.0002986373,0.00004462042,0.0001534246,0.002324851,0.00005229488,0.015309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00257949,"threshold_uncertainty_score":0.008629203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199649507728922,"score_gpt":0.2411323070190382,"score_spread":0.2291358119417489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}