{"id":"W1988022281","doi":"10.1016/j.neuroscience.2010.04.009","title":"The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons","year":2010,"lang":"en","type":"article","venue":"Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Epitope; Hyperphosphorylation; Biology; Hippocampal formation; Tau protein; Cell biology; Molecular biology; Alzheimer's disease; Neuroscience; Internal medicine; Antibody; Immunology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492362,0.0002677694,0.0002290465,0.0002686962,0.0002354423,0.0003289779,0.0001803268,0.0002507109,0.001701297],"category_scores_gemma":[0.0004109814,0.0002383596,0.0002300119,0.0002450151,0.0003478359,0.0005083362,0.0002228745,0.0005624466,0.0003335569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002438682,"about_ca_system_score_gemma":0.0002030766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006537751,"about_ca_topic_score_gemma":0.0008408517,"domain_scores_codex":[0.999927,0.000007501196,0.000006083309,0.00002238884,0.00001349514,0.00002354808],"domain_scores_gemma":[0.9998124,0.00004895846,0.00004928108,0.00002804967,0.0000230504,0.00003830733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007180036,0.00002829515,0.001025594,0.00003116429,0.000006397214,0.0001171243,0.00004059662,0.00004779721,0.9957236,0.0002281032,0.00005538221,0.001977879],"study_design_scores_gemma":[0.00005397019,0.0004804793,0.1185148,0.00001029351,0.00002926151,0.001123033,0.00008566106,0.0006591948,0.8774083,0.001178128,0.0004422035,0.00001478346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970625,0.0004629145,0.001251562,0.00005569173,0.00002164498,0.00001078837,0.0001775753,0.00003945246,0.0009177821],"genre_scores_gemma":[0.9978873,0.0003083777,0.0008973018,0.0000291366,0.00001201131,0.00001409981,0.0002021459,0.00001424774,0.000635363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001701297,"threshold_uncertainty_score":0.005691409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02897719646942954,"score_gpt":0.3130770126249859,"score_spread":0.2840998161555564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}