{"id":"W1988041293","doi":"10.1186/1742-4690-6-14","title":"Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance","year":2009,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Health Research; Gilead Sciences","keywords":"Resistance mutation; Processivity; Reverse transcriptase; Biology; Primer (cosmetics); Molecular biology; Virology; Enzyme; RNA; Chemistry; Biochemistry; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004180637,0.0004343296,0.0003955324,0.0002052214,0.0001306771,0.0004110832,0.0003504927,0.0005085437,0.001134343],"category_scores_gemma":[0.0004269905,0.0001516803,0.0003129841,0.0001603182,0.0002401888,0.0001653253,0.0001157882,0.0004449083,0.0003177983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000473401,"about_ca_system_score_gemma":0.0002859972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001730031,"about_ca_topic_score_gemma":0.001614805,"domain_scores_codex":[0.9995546,0.0001146322,0.00005942973,0.0000677798,0.0001241377,0.00007934592],"domain_scores_gemma":[0.9996819,0.0001001746,0.0001018205,0.00002768177,0.0000342453,0.00005422388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006833932,0.0001805227,0.004514141,0.00007636635,0.00004010672,0.000307808,0.00003642142,0.0005445559,0.9882607,0.00007402195,0.00006886076,0.005213052],"study_design_scores_gemma":[0.00006180078,0.003078349,0.03288756,0.00002123948,0.000102875,0.002169735,0.00008229027,0.00227054,0.9577118,0.00003938312,0.001550639,0.00002394676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986839,0.0006550083,0.0001819914,0.0000223092,0.000006882031,0.00001179549,0.000110131,0.00001549345,0.0003125382],"genre_scores_gemma":[0.9987679,0.0002577375,0.0005865665,0.00003207817,0.000004580388,0.000006129038,0.0001228674,0.00001347543,0.0002087515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001730031,"threshold_uncertainty_score":0.00379473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004459001498142942,"score_gpt":0.209601705514787,"score_spread":0.2051427040166441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}