{"id":"W1988051697","doi":"10.1016/j.bpj.2009.12.202","title":"Efficacy As An Intrinsic Property of the M2 Muscarinic Receptor in Its Oligomeric State","year":2010,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; G protein-coupled receptor; Receptor; Muscarinic acetylcholine receptor; G protein; Ligand (biochemistry); Biophysics; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001120171,0.0002926429,0.0004487048,0.0003053611,0.0003863062,0.001329559,0.0004756473,0.0005065939,0.002346968],"category_scores_gemma":[0.001450596,0.000304064,0.0003027921,0.0002169255,0.0007408773,0.001480381,0.0005151493,0.001128815,0.0005588434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003401141,"about_ca_system_score_gemma":0.0001761056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001339156,"about_ca_topic_score_gemma":0.000128078,"domain_scores_codex":[0.9995443,0.0001008759,0.00005323423,0.00009187924,0.0001189329,0.0000906663],"domain_scores_gemma":[0.998632,0.0006130397,0.0001707216,0.0002836052,0.0001811599,0.0001194126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003469096,0.00008884293,0.001261987,0.00009918162,0.00003508815,0.0001071267,0.0001602842,0.0002338752,0.9913795,0.003995606,0.0001287999,0.002162966],"study_design_scores_gemma":[0.00006273173,0.0007756962,0.02363732,0.00003391114,0.0001131096,0.001002332,0.0001778638,0.006734219,0.9620991,0.002122237,0.003197473,0.00004395733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932847,0.000691087,0.002777158,0.0001351064,0.0000235241,0.00002147858,0.0001662767,0.00006578246,0.002834996],"genre_scores_gemma":[0.9982429,0.0002305996,0.0005136519,0.00005547903,0.00002314464,0.00001720845,0.0002903112,0.00002580699,0.0006009303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002346968,"threshold_uncertainty_score":0.007851362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009905686641952634,"score_gpt":0.2495962352045315,"score_spread":0.2396905485625789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}