{"id":"W1988063333","doi":"10.1016/j.transproceed.2003.12.050","title":"Optimization of cyclosporine for liver transplantation","year":2004,"lang":"en","type":"article","venue":"Transplantation Proceedings","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Transplantation; Liver transplantation; Tacrolimus; Pharmacokinetics; Medicine; Pharmacology; Trough level; Ciclosporin; Urology; Area under the curve; Adverse effect; Diarrhea; Gastroenterology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009101567,0.0001725719,0.0002660503,0.0001789954,0.00006861478,0.00001316078,0.00005124572,0.00009172831,0.00004851389],"category_scores_gemma":[0.00000695595,0.0001543138,0.0001438975,0.0002307875,0.0000414737,0.0002872696,0.00000101833,0.00006243709,0.000006166827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004787872,"about_ca_system_score_gemma":0.00005772726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003454568,"about_ca_topic_score_gemma":0.000004010947,"domain_scores_codex":[0.9989019,0.000002790983,0.0004108381,0.0002432758,0.0002623786,0.0001788379],"domain_scores_gemma":[0.9993782,0.00003322931,0.0001477232,0.00005564992,0.0002926085,0.00009256521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05627582,0.006073805,0.1459779,0.1311254,0.002763483,0.0009666192,0.05241707,0.1426856,0.2008991,0.2480217,0.0001015195,0.01269199],"study_design_scores_gemma":[0.05706897,0.003070883,0.1880337,0.003645921,0.004660434,0.002503885,0.0004284111,0.003331961,0.7339231,0.002317318,0.0001698678,0.0008455577],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6911651,0.00009242263,0.3025894,0.0004286126,0.0001124596,0.001548784,0.0002207444,0.000147615,0.003694788],"genre_scores_gemma":[0.9315323,0.003111575,0.06417033,0.0001194336,0.0000453622,0.00008452197,0.0007591515,0.00003002653,0.0001472457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.533024,"threshold_uncertainty_score":0.6292735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925451605840784,"score_gpt":0.2767516334885486,"score_spread":0.2574971174301408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}