{"id":"W1988065251","doi":"10.1016/s0006-291x(02)00725-8","title":"Transforming growth factor-β-induced transcription of the Alzheimer β-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads","year":2002,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"Scottish Rite Charitable Foundation of Canada; University of Calgary","keywords":"CTCF; SMAD; Molecular biology; Transforming growth factor beta; Transforming growth factor; Transcription factor; Amyloid beta; Reporter gene; Biology; Repressor; Amyloid precursor protein; Chemistry; Promoter; Chromatin immunoprecipitation; Gene expression; Cell biology; Gene; Alzheimer's disease; Internal medicine; Biochemistry; Medicine; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908422,0.0001275056,0.0001277762,0.00003496929,0.0003930691,0.00004365064,0.0006574974,0.0001166934,0.00001090711],"category_scores_gemma":[0.0001931323,0.00007992997,0.0000921599,0.000207283,0.0008644279,0.00001375349,0.0002592791,0.0003383948,0.000002287759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001192893,"about_ca_system_score_gemma":0.00002892611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005101503,"about_ca_topic_score_gemma":0.000007763447,"domain_scores_codex":[0.9987433,0.000297359,0.0002246771,0.0002455125,0.0002708111,0.0002183449],"domain_scores_gemma":[0.9988376,0.0001518139,0.00005620165,0.0006741239,0.0001772249,0.0001029958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002779953,0.0001606761,0.0002492772,0.00002630619,0.00006520956,3.222615e-8,0.000191587,4.436935e-8,0.9943304,0.0001379659,0.0001737578,0.004636931],"study_design_scores_gemma":[0.0001993679,0.0001272155,0.006291249,0.00004248673,0.00003650524,0.000001080817,0.00008017355,0.0001130513,0.9907091,0.0002045327,0.002092951,0.0001022892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994764,0.001897538,0.0000386325,0.002580003,0.000009710692,0.0005133578,0.00006663574,0.00001090096,0.0001191962],"genre_scores_gemma":[0.9991442,0.0002745588,0.0002280074,0.00002942355,0.0001028335,0.0001030415,0.000068464,0.00001317832,0.00003628737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006041972,"threshold_uncertainty_score":0.325945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1787376726662315,"score_gpt":0.3600196545424988,"score_spread":0.1812819818762673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}