{"id":"W1988125544","doi":"10.1016/j.nbd.2009.06.003","title":"Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice","year":2009,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alzheimer Society","keywords":"Simvastatin; Oxidative stress; Medicine; Inflammation; Genetically modified mouse; Amyloid beta; Amyloid precursor protein; Amyloid (mycology); Cholinergic; Alzheimer's disease; Neurite; Internal medicine; Statin; Endocrinology; Pathogenesis; Neuroscience; Pharmacology; Transgene; Disease; Pathology; Chemistry; Psychology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474522,0.0008627537,0.001322485,0.0007119261,0.0003677453,0.0004262997,0.0005388036,0.0007577372,0.001598887],"category_scores_gemma":[0.0003090403,0.000327003,0.0004536996,0.000354698,0.0004208385,0.0007886814,0.0002007699,0.001104483,0.0004284112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003836623,"about_ca_system_score_gemma":0.0004620403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363471,"about_ca_topic_score_gemma":0.002507325,"domain_scores_codex":[0.9998081,0.00003309797,0.00002706899,0.00002914364,0.00003136326,0.00007122066],"domain_scores_gemma":[0.9996843,0.00002142973,0.00009795775,0.00004218099,0.00004454411,0.0001095639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02769539,0.001124644,0.001429235,0.0002809388,0.0002248814,0.0003734189,0.00008328503,0.0002178846,0.953181,0.0003114746,0.000794536,0.01428325],"study_design_scores_gemma":[0.00283956,0.01150966,0.02564786,0.00004507136,0.0007163826,0.0009637307,0.0002516795,0.002273806,0.9479263,0.001269829,0.006490332,0.00006579582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935569,0.0030336,0.001189495,0.0003699988,0.0001174343,0.00002409503,0.0005650064,0.0003030285,0.000840418],"genre_scores_gemma":[0.9900414,0.003018246,0.001514361,0.0002267835,0.0001186179,0.00006360747,0.0008102501,0.000066976,0.004139732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598887,"threshold_uncertainty_score":0.005348861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038093297926364,"score_gpt":0.2575421992166303,"score_spread":0.2471612662373667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}