{"id":"W1988215656","doi":"10.1177/1087057111402201","title":"A High-Throughput Continuous Assay for Screening and Characterization of Inhibitors of HIV Reverse-Transcriptase DNA Polymerase Activity","year":2011,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Reverse transcriptase; DNA polymerase; Polymerase; Primer (cosmetics); High-throughput screening; Fluorophore; Förster resonance energy transfer; DNA; Chemistry; Plate reader; Molecular biology; Fluorescence; Combinatorial chemistry; Biochemistry; Polymerase chain reaction; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557491,0.0001610106,0.0004155218,0.0001082367,0.00004033421,0.000008385281,0.00003467964,0.00007220904,0.00003123014],"category_scores_gemma":[0.00003818835,0.0001360095,0.0001095903,0.0001085199,0.00009452428,0.0003673817,0.00002231658,0.00005514013,0.000001411489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002367956,"about_ca_system_score_gemma":0.0000760356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001033128,"about_ca_topic_score_gemma":0.000007511517,"domain_scores_codex":[0.9991165,0.00003676941,0.0002867042,0.0002276134,0.0001625287,0.0001698896],"domain_scores_gemma":[0.9994616,0.00004645449,0.0001983293,0.0001667178,0.00005841796,0.00006851538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002376599,0.0009565802,0.1005517,0.000475222,0.0005514181,0.00003083986,0.003041866,1.20043e-7,0.8819348,0.001132344,0.0007020761,0.008246477],"study_design_scores_gemma":[0.003880214,0.0002783761,0.0731673,0.0003505689,0.0003668499,0.000007359743,0.0002486561,0.00002187886,0.9209006,0.00005402154,0.0005616778,0.0001624811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904435,0.00006005364,0.00796609,0.000331603,0.0001354881,0.0005592197,0.000306599,0.00002012747,0.0001773301],"genre_scores_gemma":[0.9938711,0.00004062631,0.002436313,0.00004368546,0.00005212666,0.00003016895,0.000237478,0.00002202036,0.003266496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03896582,"threshold_uncertainty_score":0.5546305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873007429130568,"score_gpt":0.2339992608450902,"score_spread":0.2152691865537845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}