{"id":"W1988249989","doi":"10.1021/bi900697c","title":"Nuclear Receptors <i>Homo sapiens</i> Rev-erbβ and <i>Drosophila melanogaster</i> E75 Are Thiolate-Ligated Heme Proteins Which Undergo Redox-Mediated Ligand Switching and Bind CO and NO","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"Chemistry; Heme; Ligand (biochemistry); Histidine; Non-innocent ligand; Redox; Cysteine; Nuclear receptor; Receptor; Biophysics; Stereochemistry; Biochemistry; Amino acid; Biology; Inorganic chemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004973293,0.0002771438,0.000127358,0.0001086333,0.000113082,0.0001877505,0.0002187201,0.0001572459,0.0008808282],"category_scores_gemma":[0.00005995902,0.0001083041,0.0001681187,0.0001119916,0.0001757265,0.0001235719,0.0001106478,0.0001965897,0.0003191099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637123,"about_ca_system_score_gemma":0.0001056784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258317,"about_ca_topic_score_gemma":0.001418923,"domain_scores_codex":[0.9999251,0.000006895187,0.000003565606,0.0000201874,0.00002767185,0.00001656641],"domain_scores_gemma":[0.9999567,0.000003161152,0.00001885948,0.000004434359,0.000007144837,0.000009695447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004744318,0.000005192718,0.0006466655,0.00003248415,0.000007398867,0.00005407315,0.00001709463,0.00004187644,0.9962986,0.0003067039,0.00009747435,0.00244516],"study_design_scores_gemma":[0.00002033529,0.000178197,0.02017972,0.000008457444,0.00002951175,0.001207291,0.0001279156,0.0006289653,0.9617037,0.0002061611,0.01569469,0.00001513202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849452,0.004431336,0.004514437,0.00009977668,0.00004024631,0.00002441856,0.0005770379,0.000149352,0.005218196],"genre_scores_gemma":[0.9880816,0.001655044,0.003916149,0.00007714996,0.000008111811,0.00001787655,0.000851543,0.00001233058,0.005380273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258317,"threshold_uncertainty_score":0.002946675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009813064763618392,"score_gpt":0.2172503407172785,"score_spread":0.2074372759536601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}