{"id":"W1988249989","doi":"10.1021/bi900697c","title":"Nuclear Receptors <i>Homo sapiens</i> Rev-erbβ and <i>Drosophila melanogaster</i> E75 Are Thiolate-Ligated Heme Proteins Which Undergo Redox-Mediated Ligand Switching and Bind CO and NO","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"Chemistry; Heme; Ligand (biochemistry); Histidine; Non-innocent ligand; Redox; Cysteine; Nuclear receptor; Receptor; Biophysics; Stereochemistry; Biochemistry; Amino acid; Biology; Inorganic chemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002269009,0.0004232785,0.0004132327,0.00007193846,0.0004077841,0.0002531989,0.0001832813,0.0003983658,0.00001717233],"category_scores_gemma":[0.0006223336,0.0004157735,0.0000457048,0.0003664747,0.0002009259,0.0002297763,0.0001181801,0.0005147206,0.00003482877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005642473,"about_ca_system_score_gemma":0.00007628765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000737255,"about_ca_topic_score_gemma":0.00000253612,"domain_scores_codex":[0.9976425,0.00006358214,0.000392545,0.001031804,0.0003064639,0.0005631141],"domain_scores_gemma":[0.9986399,0.0001234631,0.00025475,0.0004182452,0.00007498819,0.0004886496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009768856,0.00005684172,0.001331856,0.0001317444,0.000009431315,0.0000531842,0.0004042456,3.195532e-7,0.9963183,0.0000722265,0.001231884,0.0002922681],"study_design_scores_gemma":[0.001337006,0.0001568047,0.001808428,0.0003869717,0.00002742505,0.0004448153,0.0001713673,0.000127723,0.9901549,0.00009256857,0.004765345,0.0005266148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933597,0.001198682,0.000001973909,0.001449322,0.0001409122,0.0004028835,0.00006480456,0.0001834501,0.003198302],"genre_scores_gemma":[0.996698,0.001152005,0.0001275788,0.001235359,0.0002114331,0.000008451483,0.00001910502,0.00005185679,0.0004962321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006163379,"threshold_uncertainty_score":0.9998294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009813064763618392,"score_gpt":0.2172503407172785,"score_spread":0.2074372759536601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}