{"id":"W1988259069","doi":"10.1021/bi011526e","title":"Mechanisms for Intragenic Complementation at the Human Argininosuccinate Lyase Locus","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Francis Crick Institute","keywords":"Complementation; Argininosuccinate lyase; Mutant; Genetics; Protein-fragment complementation assay; Biology; Phenotype; Locus (genetics); Protein subunit; Arginine; Gene; Amino acid; Urea cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507513,0.0001681476,0.0001113647,0.00001121143,0.0002619326,0.00002338457,0.0002249442,0.000120625,0.0001808852],"category_scores_gemma":[0.00002667221,0.0001347978,0.0001215867,0.00005212748,0.00006732895,0.000002369713,0.0001231314,0.00005538274,0.00001333827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002648181,"about_ca_system_score_gemma":0.00003138597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001268662,"about_ca_topic_score_gemma":0.00002020463,"domain_scores_codex":[0.9990624,0.00001757653,0.0001923097,0.0003349178,0.000108045,0.0002847133],"domain_scores_gemma":[0.9993469,0.000009294279,0.00009681081,0.000407683,0.00006280978,0.00007654434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004335509,0.00002964961,0.00009346425,0.00001640761,0.00003628222,0.000001886373,0.00001619968,0.000007254408,0.984547,0.0003967626,0.0134632,0.001348581],"study_design_scores_gemma":[0.0007875494,0.00006190911,0.0003285495,0.000003952352,0.00003604318,0.00003297107,0.0001117819,0.00001999097,0.9012817,0.0002544445,0.0969078,0.0001732766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900107,0.001049481,0.006704135,0.0003437342,0.0001523503,0.0002752099,0.00008226516,0.00001904106,0.001363029],"genre_scores_gemma":[0.9875979,0.0001163776,0.000525597,0.0004715098,0.0003667503,0.00009678014,0.001001014,0.000026218,0.009797818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0834446,"threshold_uncertainty_score":0.5496892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322294474929405,"score_gpt":0.2799070362639646,"score_spread":0.2666840915146705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}