{"id":"W1988259069","doi":"10.1021/bi011526e","title":"Mechanisms for Intragenic Complementation at the Human Argininosuccinate Lyase Locus","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Francis Crick Institute","keywords":"Complementation; Argininosuccinate lyase; Mutant; Genetics; Protein-fragment complementation assay; Biology; Phenotype; Locus (genetics); Protein subunit; Arginine; Gene; Amino acid; Urea cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006855227,0.0005763573,0.0002607464,0.0005973607,0.0002775759,0.0005879034,0.0008422233,0.000696441,0.001323194],"category_scores_gemma":[0.0006947668,0.0003025664,0.0004838246,0.000158976,0.0008285413,0.0004468012,0.001081135,0.0008985329,0.0009621342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000340308,"about_ca_system_score_gemma":0.0002825252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002195073,"about_ca_topic_score_gemma":0.0001240705,"domain_scores_codex":[0.9993281,0.0001879736,0.00004881831,0.0001397334,0.0001953481,0.00009993012],"domain_scores_gemma":[0.9992827,0.0002093429,0.0001894239,0.0001735083,0.00005473538,0.00009037516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333211,0.00009694492,0.0007855351,0.00004368321,0.00001244698,0.0003920017,0.00009302044,0.0002609211,0.9891028,0.00360486,0.00008690394,0.005387452],"study_design_scores_gemma":[0.00005264064,0.0002782778,0.002462579,0.00001346986,0.00002665069,0.001872389,0.00007434473,0.002902595,0.9860075,0.001291165,0.004994936,0.00002341528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.946877,0.001375838,0.04572193,0.0003536336,0.00008145512,0.0001297423,0.0001780729,0.000544396,0.004737833],"genre_scores_gemma":[0.9870411,0.0004762755,0.009826717,0.00009113839,0.00002159592,0.000092135,0.000342725,0.000109097,0.001999152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323194,"threshold_uncertainty_score":0.004426539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322294474929405,"score_gpt":0.2799070362639646,"score_spread":0.2666840915146705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}