{"id":"W1988259573","doi":"10.1371/journal.pone.0120095","title":"ASM-024, a Piperazinium Compound, Promotes the In Vitro Relaxation of β2-Adrenoreceptor Desensitized Tracheas","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec","funders":"","keywords":"Tachyphylaxis; Bronchoconstriction; Formoterol; Methacholine; Muscarinic acetylcholine receptor; Agonist; Salmeterol; Phosphodiesterase 3; Medicine; Pharmacology; Bronchodilator; Chemistry; Bronchodilator Agents; Endocrinology; Cyclic adenosine monophosphate; Internal medicine; Phosphodiesterase; Receptor; COPD; Asthma; Lung; Biochemistry; Respiratory disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670192,0.000355514,0.0002211406,0.0001454327,0.0001184104,0.0001089186,0.0002445884,0.0002842468,0.002273474],"category_scores_gemma":[0.0001194593,0.0001485631,0.0003135554,0.00008671413,0.0001258431,0.000172972,0.0001498826,0.0005848514,0.0003418879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009920058,"about_ca_system_score_gemma":0.0001476635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003064151,"about_ca_topic_score_gemma":0.0005458518,"domain_scores_codex":[0.9998938,0.00002510209,0.00001031106,0.0000170011,0.00002334296,0.00003031736],"domain_scores_gemma":[0.9999269,0.00001379668,0.00001942447,0.000006748209,0.00001043668,0.0000226139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002297594,0.00007698926,0.00005145424,0.0000419249,0.000002770029,0.00003199718,0.000007729461,0.00002102827,0.9987098,0.00001203365,0.0000278437,0.0007867323],"study_design_scores_gemma":[0.00007599105,0.004921173,0.004540932,0.00001124907,0.00002432983,0.0002086917,0.00003157156,0.000527991,0.9878001,0.00001513077,0.001838192,0.00000465876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994997,0.002152395,0.0009899817,0.0001569919,0.00006141748,0.00003902008,0.0001729079,0.00005676148,0.001373576],"genre_scores_gemma":[0.9920539,0.001992481,0.001747942,0.0001768888,0.00004902842,0.00004934147,0.0005875193,0.00001599788,0.003326921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002273474,"threshold_uncertainty_score":0.007605493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06064917030219073,"score_gpt":0.2620896570572801,"score_spread":0.2014404867550894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}