{"id":"W1988271836","doi":"10.1016/j.fob.2014.08.003","title":"Quercetin‐3‐glucoside increases low‐density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture","year":2014,"lang":"en","type":"article","venue":"FEBS Open Bio","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; Kexin; LDL receptor; Proprotein convertase; Subtilisin; Chemistry; Secretion; Low-density lipoprotein; Quercetin; Endocrinology; Lipoprotein; Pharmacology; Internal medicine; Biochemistry; Cholesterol; Medicine; Enzyme; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001027456,0.0005860695,0.00106609,0.0001638676,0.0003423499,0.0003126068,0.0004481876,0.0004097263,0.0005566131],"category_scores_gemma":[0.0007423379,0.0004538398,0.0001144406,0.0002607234,0.0002936605,0.0005025408,0.0004834884,0.000573619,0.0001366308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000814511,"about_ca_system_score_gemma":0.00009516487,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01223733,"about_ca_topic_score_gemma":0.001138091,"domain_scores_codex":[0.9966391,0.0004295243,0.0008180859,0.001036889,0.0004715162,0.0006048776],"domain_scores_gemma":[0.9979863,0.00009583074,0.0003110208,0.0007993802,0.0002874212,0.0005201185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001379888,0.0008839033,0.1365254,0.000423762,0.00006307325,0.00002660611,0.001409776,0.000001751596,0.82767,0.0001201463,0.02364609,0.007849655],"study_design_scores_gemma":[0.009541055,0.0007083492,0.2171418,0.002424599,0.0001347725,0.00004863073,0.0005675195,0.0002600108,0.6827768,0.0004807514,0.08498932,0.0009263876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993394,0.001538048,0.00002270483,0.001275965,0.0001310391,0.003070967,0.0001191349,0.0001291576,0.0003189577],"genre_scores_gemma":[0.9926013,0.0001806355,0.001030735,0.001205216,0.0004750435,0.0002888509,0.0009715361,0.00007810156,0.003168545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1448931,"threshold_uncertainty_score":0.9997913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193700268983462,"score_gpt":0.266207149663437,"score_spread":0.2542701469736024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}