{"id":"W1988271836","doi":"10.1016/j.fob.2014.08.003","title":"Quercetin‐3‐glucoside increases low‐density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture","year":2014,"lang":"en","type":"article","venue":"FEBS Open Bio","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; Kexin; LDL receptor; Proprotein convertase; Subtilisin; Chemistry; Secretion; Low-density lipoprotein; Quercetin; Endocrinology; Lipoprotein; Pharmacology; Internal medicine; Biochemistry; Cholesterol; Medicine; Enzyme; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008414307,0.0001622527,0.0001337546,0.0001386899,0.00007713338,0.0001532513,0.00007928277,0.0002047469,0.001161825],"category_scores_gemma":[0.00008182759,0.00007473539,0.0001575186,0.0000904976,0.0001540267,0.00011213,0.00006980617,0.0003717337,0.0001490561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301457,"about_ca_system_score_gemma":0.0001714389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001499641,"about_ca_topic_score_gemma":0.001811312,"domain_scores_codex":[0.9999331,0.00001956026,0.000005262464,0.00001064772,0.00001551682,0.00001588052],"domain_scores_gemma":[0.999964,0.000008366328,0.00000684629,0.000004167994,0.00000566525,0.00001097983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001310847,0.00004236723,0.0001203894,0.00001708503,0.000004469124,0.00001531612,0.000005658415,0.00002055865,0.9985079,0.00004714004,0.00004229141,0.001045647],"study_design_scores_gemma":[0.00005632106,0.0009148251,0.005339541,0.000003337086,0.00001875879,0.0001070089,0.00002527764,0.0005065999,0.9915709,0.00006307552,0.001390274,0.000003972244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960846,0.0009888706,0.001433339,0.0001936773,0.00003078753,0.00001562155,0.0001391305,0.00006611891,0.001047934],"genre_scores_gemma":[0.9966696,0.0005245249,0.0009941504,0.00008945272,0.000008325726,0.000009123821,0.0002386056,0.000006551629,0.001459621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499641,"threshold_uncertainty_score":0.00388664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193700268983462,"score_gpt":0.266207149663437,"score_spread":0.2542701469736024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}