{"id":"W1988299037","doi":"10.1016/j.immuni.2013.09.004","title":"Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes","year":2013,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Medical Research Council; Cancer Research UK; Wellcome Trust","keywords":"Furin; TLR7; Proprotein Convertases; Endosome; Biology; Endocytic cycle; Cell biology; Immune system; Toll-like receptor; Receptor; Proprotein convertase; Endocytosis; Immunology; Innate immune system; Biochemistry; LDL receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003649481,0.0002903543,0.0003331514,0.0002467367,0.0003358934,0.0008165182,0.0002052261,0.0004767078,0.001075674],"category_scores_gemma":[0.0004850534,0.0003304034,0.0005431843,0.000113428,0.0002465491,0.0006640207,0.0004130585,0.0007671762,0.001135099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008765265,"about_ca_system_score_gemma":0.0004060113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007577647,"about_ca_topic_score_gemma":0.0007369193,"domain_scores_codex":[0.999687,0.00005726425,0.0000357476,0.00004429159,0.00006879,0.0001069381],"domain_scores_gemma":[0.999496,0.00009882377,0.0001316672,0.0000678783,0.0001163552,0.00008928707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002083638,0.00001152995,0.0003155821,0.00001934623,0.000005867529,0.0001320321,0.00001476577,0.00003495366,0.9983885,0.0002201083,0.00006183735,0.0005871031],"study_design_scores_gemma":[0.00001527445,0.00004629787,0.0104973,0.000005932715,0.00001072625,0.0006488256,0.00006782475,0.0009995969,0.9858097,0.0001490234,0.001743325,0.000006215753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914541,0.001833731,0.0049742,0.000290259,0.0000498444,0.00002620121,0.000381765,0.00006754824,0.0009223797],"genre_scores_gemma":[0.9937956,0.0004046806,0.002749481,0.00007109017,0.00001507447,0.00001659042,0.0009924392,0.00004217621,0.001912914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075674,"threshold_uncertainty_score":0.006359696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03371573637868072,"score_gpt":0.2962127631056654,"score_spread":0.2624970267269846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}