{"id":"W1988299626","doi":"10.1371/journal.pone.0009663","title":"Microenvironment Modulates Osteogenic Cell Lineage Commitment in Differentiated Embryonic Stem Cells","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Embryonic stem cell; Cellular differentiation; Stem cell; Progenitor cell; Osteoblast; Regenerative medicine; Tissue engineering; Cell culture; Chemistry; Biology; In vitro; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008508946,0.0001501052,0.0001210001,0.0001255351,0.000117062,0.0002905764,0.0000863453,0.0001065133,0.001346201],"category_scores_gemma":[0.0001176563,0.00008820236,0.0001012733,0.00009262299,0.0001601538,0.0001530817,0.0002182666,0.0001888866,0.0001967677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681401,"about_ca_system_score_gemma":0.0001406369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000281904,"about_ca_topic_score_gemma":0.0007293806,"domain_scores_codex":[0.9999126,0.0000157923,0.000009346746,0.00001539542,0.00002407749,0.00002282317],"domain_scores_gemma":[0.9999294,0.00002196021,0.00001682383,0.000005206107,0.0000105776,0.00001598746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008030015,0.00001445726,0.0005983448,0.00003462492,0.000002563112,0.00005926888,0.00002338317,0.00006157819,0.9976682,0.00009245489,0.00002829288,0.001336407],"study_design_scores_gemma":[0.00001412278,0.0001277505,0.02188776,0.00001017379,0.00001763851,0.0001817716,0.00009913449,0.0008034739,0.9749952,0.00009243779,0.001764754,0.000005732123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952208,0.001461938,0.001215189,0.00004141984,0.00001946117,0.00001100117,0.00017137,0.00001926628,0.001839507],"genre_scores_gemma":[0.9977489,0.0007221243,0.0005466978,0.00003479204,0.000005565584,0.00001526785,0.0001216137,0.000007154535,0.0007978298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346201,"threshold_uncertainty_score":0.004503489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01753949837730631,"score_gpt":0.2097553038740974,"score_spread":0.1922158054967911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}