{"id":"W1988321285","doi":"10.1074/jbc.m114.620849","title":"Three αSNAP and 10 ATP Molecules Are Used in SNARE Complex Disassembly by N-ethylmaleimide-sensitive Factor (NSF)","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health","keywords":"SNARE complex; ATP hydrolysis; Lipid bilayer fusion; Signal transducing adaptor protein; Cell biology; SNAP25; Biophysics; Vesicular Transport Proteins; Biology; Chemistry; Vesicle; Membrane; Biochemistry; Intracellular; ATPase; Synaptic vesicle; Signal transduction; Endosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759568,0.0004441149,0.0003053664,0.0001513026,0.0001313136,0.0002417504,0.0004589604,0.000456476,0.0009489006],"category_scores_gemma":[0.0002562724,0.0002275776,0.000344977,0.0002153786,0.0002683206,0.0002384864,0.0002054207,0.0005111198,0.000266079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006213937,"about_ca_system_score_gemma":0.0002761821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001288014,"about_ca_topic_score_gemma":0.00164727,"domain_scores_codex":[0.9996777,0.00004745808,0.00004444693,0.00008219782,0.0000931721,0.00005501234],"domain_scores_gemma":[0.9998406,0.00003276539,0.00003878106,0.00002302672,0.00001194337,0.000052864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000175833,0.00004277534,0.0002232261,0.00003191335,0.00001106852,0.00004061421,0.000007515712,0.0001073493,0.9982741,0.00006519189,0.00002121873,0.0009991764],"study_design_scores_gemma":[0.000007706554,0.0001208099,0.001084203,0.000002560326,0.00001049131,0.00008033539,0.000004605521,0.0006246654,0.9975398,0.00001271845,0.0005098956,0.000002317432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946159,0.0007130232,0.003788027,0.00005584015,0.00002572897,0.0000303692,0.00009096588,0.00005448225,0.0006257529],"genre_scores_gemma":[0.9906935,0.0005014479,0.006199869,0.00005753873,0.000006676719,0.00005955221,0.0005853737,0.00002140278,0.00187461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288014,"threshold_uncertainty_score":0.004508555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02474274768902284,"score_gpt":0.2409201286833865,"score_spread":0.2161773809943636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}