{"id":"W1988387392","doi":"10.1038/ncomms7763","title":"A fungal protease allergen provokes airway hyper-responsiveness in asthma","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie – Hans-Knöll-Institut; Leibniz-Gemeinschaft; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Institutes of Health","keywords":"Bronchoconstriction; Immunology; Proteases; Histamine; Asthma; Medicine; Serine protease; Bradykinin; Sensitization; Allergen; Allergy; Protease; Chemistry; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002479992,0.0003080965,0.0002271529,0.0001903512,0.0002411153,0.0002899999,0.0001747145,0.0007567893,0.001533616],"category_scores_gemma":[0.0001568731,0.0001309556,0.0003545788,0.0001620787,0.0002338612,0.0002008015,0.0002802449,0.0009814963,0.0005311392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002272352,"about_ca_system_score_gemma":0.0001416613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002067666,"about_ca_topic_score_gemma":0.0003229623,"domain_scores_codex":[0.9998441,0.00003763537,0.00001332776,0.00001998936,0.00005099223,0.00003389563],"domain_scores_gemma":[0.9999142,0.0000190032,0.00002151908,0.0000107114,0.00000888714,0.00002559895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004598928,0.0001290898,0.001872535,0.0001818121,0.00001413645,0.001175152,0.00003263765,0.00004001928,0.9863948,0.0002413414,0.0007942311,0.008664307],"study_design_scores_gemma":[0.0001627168,0.003045852,0.1472903,0.00008500741,0.0001194,0.02077588,0.0002168034,0.0009355727,0.8021813,0.0006412765,0.02452485,0.00002089061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575757,0.02873621,0.003127126,0.002360371,0.0006192462,0.0001079767,0.0004046751,0.0001714956,0.006897283],"genre_scores_gemma":[0.9873104,0.008382048,0.001206413,0.0005847854,0.0002231815,0.00003040221,0.0002172821,0.000007899373,0.002037689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533616,"threshold_uncertainty_score":0.00513047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417925564088396,"score_gpt":0.3305989778352736,"score_spread":0.2964197221943896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}